Features of malignant neoplasms formation in respiratory system of workers engaged into mining and processing of copper-nickel ores
https://doi.org/10.31089/1026-9428-2018-9-9-15
Abstract
Analysis of 102 lung cancer cases in workers of mining and metallurgic enterprises ofNorilskindustrial region revealed features of course, prevalence of morphologic variants and other disease characteristics related to age and length of service. Te exposure parameters were analyzed by individual carcinogenic risk calculation. In more intense exposure to nickel-containing aerosols in metallurgic production, there are more rapid formation and progress of the oncologic process. Efficiency of timely diagnosis of the disease within periodic medical examinations was proved. Nickel-containing aerosols load was demonstrated as playing an important role in formation of various morphologic variants of lung cancer. Te highest level of affinity to nickel compounds exposure is characteristic for adenocarcinoma, the medium one — for epidermoid cancer and minimal — for small cell carcinoma.
About the Authors
P. V. Serebryakov
Federal Scientific Center of Hygiene named after F.F. Erisman
Russian Federation
2, Semashko str., Mytischi, Moscow region, 141014
Russian Federation
2, Semashko str., Mytischi, Moscow region, 141014
I. N. Fedina
Federal Scientific Center of Hygiene named after F.F. Erisman
Russian Federation
2, Semashko str., Mytischi, Moscow region, 141014
Russian Federation
2, Semashko str., Mytischi, Moscow region, 141014
O. P. Rushkevich
Federal Scientific Center of Hygiene named after F.F. Erisman
Russian Federation
2, Semashko str., Mytischi, Moscow region, 141014
Russian Federation
2, Semashko str., Mytischi, Moscow region, 141014
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Review
For citations:
Serebryakov P.V., Fedina I.N., Rushkevich O.P. Features of malignant neoplasms formation in respiratory system of workers engaged into mining and processing of copper-nickel ores. Russian Journal of Occupational Health and Industrial Ecology. 2018;(9):9-15. (In Russ.) https://doi.org/10.31089/1026-9428-2018-9-9-15
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