Search for associations of polymorphic variants of nucleotide excision repair genes with the increased risk of bronchopulmonary pathology in workers of hazardous and dangerous industries
https://doi.org/10.31089/1026-9428-2018-8-43-47
Abstract
The study covered workers of asbestos cement plants and miners (n = 214). Polymerase chain reaction method in real time helped to identify genotypes of genes XPD (rs13181, rs799793) and ERCC1 (rs11615).
The study results prove that XPD*C/C genotype is associated with bronchopulmonary disease risk (p≤0.02, χ2=4.97; OR=2.40; 95% CI: 1.03–5.64).Carriers of XPD*A/C genotype appeared to have relative resistance to bronchopulmonary diseases risk (χ2=3,52, р≤0,06; OR=0,57; 95%CI: 0,30–1,07).
About the Authors
Т. A. Andrushchenko
Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine
Ukraine
75, Saksaganskogo str., Kyiv, 01033
Ukraine
75, Saksaganskogo str., Kyiv, 01033
S. V. Goncharov
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
Ukraine
Ukraine
4, Bogomolets str., Kyiv, 1024
V. Е. Dosenko
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
Ukraine
Ukraine
4, Bogomolets str., Kyiv, 1024
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Review
For citations:
Andrushchenko Т.A., Goncharov S.V., Dosenko V.Е. Search for associations of polymorphic variants of nucleotide excision repair genes with the increased risk of bronchopulmonary pathology in workers of hazardous and dangerous industries. Russian Journal of Occupational Health and Industrial Ecology. 2018;(8):43-47. (In Russ.) https://doi.org/10.31089/1026-9428-2018-8-43-47
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