TOXICOLOGIC EVALUATION OF 2-METHOXYBENZOIC ACID AS A RISK FACTOR FOR WORKERS’ HEALTH.
https://doi.org/10.31089/1026-9428-2018-6-19-23
Abstract
The authors studied toxic properties of 2-methoxybenzoic acid for its hygienic regulation in the air of workplace. Values of average lethal dose (DL50) for male rats, male mice and female mice equal 5945, 3183 and 3030 mg/kg respectively. 2-methoxybenzoic acid is a highly dangerous substance (2nd jeopardy class). Clinical manifestations of the acute poisoning included adynamia, lower body temperature, tremor, periodic clonic and tonic convulsions. The chemical has average cumulative ability — cumulation coefficient is 3.03, with moderate irritative action on skin, but no skin resorption and sensibilizing activity, intense irritative influence on eyes mucosa (2nd jeopardy class). Acute inhalation action threshold is 33.9 mg/m3. Approximate safe level of exposure to 2-methoxybenzoic acid in the air of workplace is 0.5 mg/m3.
About the Authors
N. A. Martynova
Research Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
L. G. Gorokhova
Research Institute for Complex Problems of Hygiene and Occupational Diseases;
Novokuznetsk Institute (Branch) of Kemerovo State University
Russian Federation
Russian Federation
23, Tsiolkovskogo str., Novokuznetsk, Russian Federation, 654041
V. A. Shtaiger
Research Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
L. Shpagina
OOO Profilaktika ROST, a limited liability company under the laws of the Russian Federation
Russian Federation
16, Pionersky Ave., Novokuznetsk, Russian Federation, 654027
Russian Federation
16, Pionersky Ave., Novokuznetsk, Russian Federation, 654027
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Review
For citations:
Martynova N.A., Gorokhova L.G., Shtaiger V.A., Shpagina L. TOXICOLOGIC EVALUATION OF 2-METHOXYBENZOIC ACID AS A RISK FACTOR FOR WORKERS’ HEALTH. Russian Journal of Occupational Health and Industrial Ecology. 2018;(6):19-23. (In Russ.) https://doi.org/10.31089/1026-9428-2018-6-19-23
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