PECULIARITIES OF THE STRUCTURAL COLLAGEN DISORGANIZATION AS A TRIGGER MECHANISM OF PNEUMOSCLEROSIS IN MINERS.
https://doi.org/10.31089/1026-9428-2018-6-7-11
Abstract
Morphologic and immunohistochemical studies of lung tissue covered miners with average length of underground service 20.4±2.0 year Findings are that in pneumoconiosis the studied tissue demonstrates marked expression of collagen I, III, IV types mostly in vascular and bronchial area Increased production of collagen is due to epithelial mesenchymal transformation process. Pneumoconiotic process is based on synergetic relationship between basal membranes collagen decay as an initial factor of the process and fibroplastic changes in vessels and bronchi.
About the Authors
O. I. Bondarev
Novokuznetsk State Institute for Further Training of Physicians — Branch Campus of Russian Medical Academy of Continuous Professional Education
Russian Federation
5, Stroiteley Ave., Novokuznetsk, Russian Federation, 654005
Russian Federation
5, Stroiteley Ave., Novokuznetsk, Russian Federation, 654005
M. S. Bugaeva
Novokuznetsk State Institute for Further Training of Physicians — Branch Campus of Russian Medical Academy of Continuous Professional Education;
Research Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
N. N. Mikhailova
Research Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
S. N. Filimonov
Research Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
Russian Federation
23, Kutuzova str., Novokuznetsk, Russian Federation, 654041
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Review
For citations:
Bondarev O.I., Bugaeva M.S., Mikhailova N.N., Filimonov S.N. PECULIARITIES OF THE STRUCTURAL COLLAGEN DISORGANIZATION AS A TRIGGER MECHANISM OF PNEUMOSCLEROSIS IN MINERS. Russian Journal of Occupational Health and Industrial Ecology. 2018;(6):7-11. (In Russ.) https://doi.org/10.31089/1026-9428-2018-6-7-11
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