Clinical and laboratory diagnostic criteria of chronic glomerular and tubulointerstitial kidney disorders associated with exposure to metals and oxygen organic compounds of technogenic origin

Complex clinical, functional an laboratory examination of children living under unacceptable risk conditions due to aerogenous exposure to cadmium, chromium, lead and phenol revealed that kidney diseases associated with exposure to metals and phenol develop in children with genetic predisposition to disordered biotransformation of chemicals — polymorphism of genes CYPOX, RCYT 450, SULTA1 in homozygous and heterozygous variants. Increased levels of chemicals in blood causes microcirculation disorders in renal cortex, direct toxic effect in nephrons, suppresses activity of anitoxidant defense on cellular and systemic levels. The authors specifi ed pathogenetically based complex of clinical and laboratory diagnostic markers of chronic kidney diseases associated with exposure to metals (cadmium, chromium, lead) and oxygen-containing (phenol) organic compounds.

1. A polikhin O. I., Sivkov A.V., Beshliev D. A. / / Eksperimental’naya i klinicheskaya urologiya. — 2010. — 1. — Р. 4–11 (in Russian).

2. Vyalkova A.A. // Pediatriya. — 2008. — V. 87. — 3. — Р. 129–131 (in Russian).

3. Zhmin’ko P.G. //Actual problems of transport medicine. — 2011. — 1 (23). — Р. 17–30 (in Russian).

4. Zaytseva N.V., Ustinova O.Yu., Aminova A.I. Hygienic aspects of children health disorders under exposure to environmental chemical factors. — Perm’: Knizhnyi format, 2011. — 489 p. (in Russian).

5. Ignatova M.S. // Pediatriya. — 2007. — V. 86. — 6. — Р. 6–15 (in Russian).

6. Ignatova M.S., Lebedenkova M.V., Dlin V.V., et al. // Rossiyskiy vestnik perinatologii i pediatrii. — 2008. — 6. — Р. 4–10 (in Russian).

7. General morbidity among children (0–14 years) in Russia in 2012. Statistic materials. Part VI. Collection of materials from Federal Budgetary establishment «Central research institute of management and information in health care» with RF Health Ministry and assistance by specialists of Department for analysis, prognosis and innovation development of health care system with RF Health Ministry. — Moscow, 2013. — 144 p. (in Russian).

8. Parakhonskiy A.P. // Sovremennye naukoemkie tekhnologii. — 2010. — 7. — Р. 220–222 (in Russian).

9. Ustinova O.Yu., Ryzhakov S.A., Zemlyanova M.A., Aminova A.I., et al. // Vestnik Ural’skoy gosudarstvennoy meditsinskoy akademii. — 2012; . — issue 24. — Р. 179–180 (in Russian).