Clinical and laboratory diagnostic criteria of chronic glomerular and tubulointerstitial kidney disorders associated with exposure to metals and oxygen organic compounds of technogenic origin
Abstract
Complex clinical, functional an laboratory examination of children living under unacceptable risk conditions due to aerogenous exposure to cadmium, chromium, lead and phenol revealed that kidney diseases associated with exposure to metals and phenol develop in children with genetic predisposition to disordered biotransformation of chemicals — polymorphism of genes CYPOX, RCYT 450, SULTA1 in homozygous and heterozygous variants. Increased levels of chemicals in blood causes microcirculation disorders in renal cortex, direct toxic effect in nephrons, suppresses activity of anitoxidant defense on cellular and systemic levels. The authors specifi ed pathogenetically based complex of clinical and laboratory diagnostic markers of chronic kidney diseases associated with exposure to metals (cadmium, chromium, lead) and oxygen-containing (phenol) organic compounds.
About the Authors
O. Yu. UstinovaRussian Federation
82, Monastyrskaya str., Perm, 614045
15, Bukirev str., Perm, 614990
O. A. Maklakova
Russian Federation
82, Monastyrskaya str., Perm, 614045
15, Bukirev str., Perm, 614990
J. A. Ivashova
Russian Federation
82, Monastyrskaya str., Perm, 614045
V. E. Belitskaya
Russian Federation
82, Monastyrskaya str., Perm, 614045
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Review
For citations:
Ustinova O.Yu., Maklakova O.A., Ivashova J.A., Belitskaya V.E. Clinical and laboratory diagnostic criteria of chronic glomerular and tubulointerstitial kidney disorders associated with exposure to metals and oxygen organic compounds of technogenic origin. Russian Journal of Occupational Health and Industrial Ecology. 2015;(8):33-38. (In Russ.)