Genetically determined lipid metabolism disorders due to oral intake of technogenic hyperchlorination products
Abstract
The study covered genetically determined lipid metabolism disorders due to oral intake of technogenic hyperchlorination drinkable water products. Findings are that overweight and obese children in a main group appeared to have serum chloroform level 2.3 times higher than that in a reference group. In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity — APOE, PPARG, HTR2A, characterizing antioxidant system state — SOD2 and detoxication — SULTA. Polymorphism of candidate genes HTR2A and SOD2 was characterized by increased occurrence of mutant homo — and heterozygous genotype, relative risk of pathologic allele presence in population exceeded the refrence group values. Probability of increased serum serotonin and lower Cu/Zn in children with mutant homozygous genotype HTR2A and SOD2 is 1.2–1.3 times higher than in those with heterozygous and normal homozygous genotypes.
About the Authors
K. P. Luzhetsky
Federal Budget Scientifi c Institution «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»;
Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
82, Monastyrskaya str., Perm, 614045
15, Bukirev str., Perm, 614990
O. V. Dolgikh
Federal Budget Scientifi c Institution «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»;
Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
82, Monastyrskaya str., Perm, 614045
15, Bukirev str., Perm, 614990
O. Yu. Ustinova
Federal Budget Scientifi c Institution «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»;
Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
82, Monastyrskaya str., Perm, 614045
15, Bukirev str., Perm, 614990
A. V. Krivtsov
Federal Budget Scientifi c Institution «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»
Russian Federation
Russian Federation
82, Monastyrskaya str., Perm, 614045
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Review
For citations:
Luzhetsky K.P., Dolgikh O.V., Ustinova O.Yu., Krivtsov A.V. Genetically determined lipid metabolism disorders due to oral intake of technogenic hyperchlorination products. Russian Journal of Occupational Health and Industrial Ecology. 2015;(8):24-28. (In Russ.)
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