Protective properties of reamberine in acute experimental combined exposure to cold, vibration and immobilization
https://doi.org/10.31089/1026-9428-2018-4-46-50
Abstract
Experimental study covered protective properties of succinate-containing ant-hypoxant reamberine in acute exposure to cold, vibration and immobilization in rats.
Rats of reference group and group receiving 50 mg/kg of reamberine were subjected to cold (-15C during 60 min) and immobilization after session of general vibration with amplitude 0.5 mm and frequency 44 Hz during 90 min. Parameters assessed were rectal temperature and succinate dehydrogenase activity of peripheral WBC by quantitative cytochemical test based on reduction of paranitroviolet tetrasolium to formazan.
About the Authors
V. V. Vorobieva
Smolensk State Medical University
Russian Federation
Smolensk, 28, Krupskaya str., 214019
Russian Federation
Smolensk, 28, Krupskaya str., 214019
P. D. Shabanov
Military Medical Academy
Russian Federation
6, Acad. Lebedeva str., St. Petersburg, 194044
Russian Federation
6, Acad. Lebedeva str., St. Petersburg, 194044
References
1. Agadzhanyan N.A., Torshin V.I. Human ecology. — Moscow: KRUK, 1994. — 256 p (in Russian).
2. Arokina N.K. Obzory po klin. farmakologii i lekarstv. Terapii, 2015, vol 13: materialy konf., posvyashch. 150-letiyu N.P. Kravkova. — St-Petersburg: 11–12 (in Russian).
3. Bodienkova G.B, Kurshevenko S.I. Neuro-immune-endocrine relationships under workers’ exposure to local vibration // Med. truda. i prom. еkol. — 2015. — 4. — Р. 39–43 (in Russian).
4. Brustovetskiy N.N., Grishina E.V., Amerkhanov Z.G., Maevskiy E.I. — Zhurn. evol. biokhim. fi ziol. — 1989. — 5. — P. 448–453 (in Russian).
5. Brustovetskiy N.N., Grishina E.V., Maevskiy E.I., Amerkhanov Z.G., Kim Yu.A // Byul. eksperim. biol. i meditsiny. — 1989. — 10. — P. 488–490 (in Russian).
6. Volchegorskiy I.A., Dolgushin I.I., Kolesnikov O.A., Tseylikman V.E Experimental modelling and laboratory evaluation of human adaptive reactions. — Chelyabinsk, 2000. — 167 p (in Russian).
7. Vorob’eva V.V., Mazina N.K., Shabanov P.D., Vorob’eva V.V., Shabanov P.D. Experimental basis of calcium channal-blocking agents use in vibration disease // Med. truda. i prom. ekol. — 2013. — 2. — P. 37–41 (in Russian).
8. Vorob’eva V.V., Shabanov P.D. Byul. eksperim. biol. i meditsiny, 2009; vol 147, 6: 712–715 (in Russian).
9. Vorob’eva V.V., Shabanov P.D. Vibration and vibro-protectors. — St-Petersburg: Inform.-navigator, 2015. — 410 p (in Russian).
10. Ivanov K.P. Basics of body energy: Th eoretic and practic aspects. Vol 1. General energy, heat exchange and thermoregulation. — Leningrad: Nauka, 1990. — 307 p (in Russian).
11. Karamullin M.A., Yazenok A.V. Lesions caused by cold. Pathogenesis, clinical signs. Principles of diagnosis and treatment. — St-Petersburg, 2002. — 25 p (in Russian).
12. Kondrashova M.N. Metabolic states of mitochondria in various physiologic states. Molecular mechanisms of cellular homeostasis. — Novosibirsk: Nauka, 1987. — P. 140–153 (in Russian).
13. Krylov K.M., Kozulin D.A., Nemchenko D.V. Th ird scientifi c conference on «Injury due to cold» problem: reports on III scientifi c practical conference. — St-Petersburg, 2002. — P. 47–48 (in Russian).
14. Petrichuk S.V., Shishchenko V.M., Dukhova Z.N. Mitochondria in pathology: materials of operative conference. — Pushchino, 2001. — P. 19–20 (in Russian).
15. Khaskin V.V. Energy of thermogenesis and adaptation to cold. — Novosibirsk: Nauka, 1975. — 200 p (in Russian).
16. Khasnulin V.I. Introduction into polar medicine. — Novosibirsk: SO RA MN, 1993. — 337 p (in Russian)
17. Correa P.R., Kruglov E.A, Th ompon М. // J. Нepatology. — 2007. — V. 47, N2. — Р. 262–269.
18. He W., Miao F.J., Lin D.C. // Nature. — 2004. — V. 429. — Р. 188–193.
19. Issever H., Aksoy С., Sabuncu Н., Karan А. // Med. Princ. Pract. — 2003. — V. 12, N1. — Р. 34–38.
20. Stroka D.M., Burkhardt Т., Desballerts I. // FASEB J. — 2001. — V. 15. — P. 2445 –2453.
21. Weihai F., Frederick J.-P., Miro S. // Nature. — 2004. — V. 429. — Р. 188–193.
22. Witt enberger T. Schaller Н.С., Hellebrant S. // J. Mol. Biol. — 2001. — V. 307 — P. 799–813.
23. Witt enberger T. // BMC Genomics. — 2002. — N 3. — P. 17–22.
Review
For citations:
Vorobieva V.V., Shabanov P.D. Protective properties of reamberine in acute experimental combined exposure to cold, vibration and immobilization. Russian Journal of Occupational Health and Industrial Ecology. 2018;(4):46-50. (In Russ.) https://doi.org/10.31089/1026-9428-2018-4-46-50
Views:
465
Email this article 
