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Polymorphic loci of HSP1A genes and biological age in workers chronically exposed to mercury vapor

Abstract

Examination covered 98 former workers of causticum production, with chronic exposure to mercury vapors, who were divided into 2 groups: first (n=44) - without chronic mercury intoxication diagnosis, second (n=54) - with chronic mercury intoxication diagnosis. Via PCR-PDRF analysis, the authors studied polymorph variants of genes HSPA1A (+190G/C), HSPA1B (+1267A/G) and HSPA1L (+2437T/C), “Ageing diagnosis: biologic age» program helped to assess biologic age and ageing intensity as difference between biologic age and calendar age. Findings are increased frequency of GG-HSPA1B (+1267A/G) genotype in the group with chronic mercury intoxication diagnosis (p=0.011), increased biologic age in GG genotype carriers (p=0.042), if compared to the rest of group 2. The results obtained prove involvement of the studied polymorph locus (+1267A/G) of HSPA1B gene into mechanisms of chronic mercury intoxication development and progression, and could be considered in elaboration of personified approaches to prevention and treatment of chronic mercury intoxication.

About the Authors

Yu. I. Chernyak
East-Siberian Institute of Medical and Ecological Research
Russian Federation


O. I. Shevchenko
East-Siberian Institute of Medical and Ecological Research
Russian Federation


O. L. Lakhman
East-Siberian Institute of Medical and Ecological Research
Russian Federation


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Review

For citations:


Chernyak Yu.I., Shevchenko O.I., Lakhman O.L. Polymorphic loci of HSP1A genes and biological age in workers chronically exposed to mercury vapor. Russian Journal of Occupational Health and Industrial Ecology. 2017;(10):38-42. (In Russ.)

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ISSN 1026-9428 (Print)
ISSN 2618-8945 (Online)