Polymorphic loci of HSP1A genes and biological age in workers chronically exposed to mercury vapor

Examination covered 98 former workers of causticum production, with chronic exposure to mercury vapors, who were divided into 2 groups: first (n=44) - without chronic mercury intoxication diagnosis, second (n=54) - with chronic mercury intoxication diagnosis. Via PCR-PDRF analysis, the authors studied polymorph variants of genes HSPA1A (+190G/C), HSPA1B (+1267A/G) and HSPA1L (+2437T/C), “Ageing diagnosis: biologic age» program helped to assess biologic age and ageing intensity as difference between biologic age and calendar age. Findings are increased frequency of GG-HSPA1B (+1267A/G) genotype in the group with chronic mercury intoxication diagnosis (p=0.011), increased biologic age in GG genotype carriers (p=0.042), if compared to the rest of group 2. The results obtained prove involvement of the studied polymorph locus (+1267A/G) of HSPA1B gene into mechanisms of chronic mercury intoxication development and progression, and could be considered in elaboration of personified approaches to prevention and treatment of chronic mercury intoxication.

ртуть, хроническое воздействие, хроническая ртутная интоксикация, белки теплового шока 70, полиморфизм генов, биологический возраст, темпы старения, mercury, chronic exposure, chronic mercury intoxication, heat shock proteins 70, gene polymorphism, biologic age, ageing rate

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