zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2026-66-2-123-132tziyfazurniimtpe-4089Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSПрофессиональная бронхиальная астма: роль аутофагии в развитии и прогрессировании заболеванияOccupational bronchial asthma: the role of autophagy in the development and progression of the diseasehttps://orcid.org/0009-0007-4113-109XСолощенкоАнастасия ЕвгеньевнаSoloshchenkoAnastasia E.

Врач-педиатр, Муниципальное бюджетное учреждение здравоохранения «Городская поликлиника № 10», детское поликлиническое отделение.

e-mail: anastasias13.08@mail.ru

Pediatrician, City Polyclinic No. 10, Pediatric Outpatient Department.

e-mail: anastasias13.08@mail.ru

anastasias13.08@mail.ruhttps://orcid.org/0009-0008-6830-8972СоколоваЕлена АндреевнаSokolovaElena A.

Студент 6 курса педиатрического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: yelena-sokolova-018@mail.ru

6th-year student, Faculty of Pediatrics, Rostov State Medical University.

e-mail: yelena-sokolova-018@mail.ru

yelena-sokolova-018@mail.ruhttps://orcid.org/0009-0005-8243-2409МаксутоваМария ВладимировнаMaksutovaMaria V.

Студент 6 курса лечебно-профилактического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: mmv_2002@mail.ru

6th-year student, Faculty of General Medicine (Preventive Care), Rostov State Medical University.

e-mail: mmv_2002@mail.ru

mmv_2002@mail.ruhttps://orcid.org/0009-0002-9164-2166БислиеваМата РамзановнаBislievaMata R.

Студент 6 курса педиатрического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: matabislieva@mail.ru

6th-year student, Faculty of Pediatrics, Rostov State Medical University.

e-mail: matabislieva@mail.ru

matabislieva@mail.ruhttps://orcid.org/0009-0001-0469-6207ВолосекоАнна ПетровнаVolosekoAnna P.

Студент 6 курса педиатрического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: an.voloseko@mail.ru

6th-year student, Faculty of Pediatrics, Rostov State Medical University.

e-mail: an.voloseko@mail.ru

https://orcid.org/0009-0001-4876-2106ЦаплинЕвгений МихайловичTsaplinEvgenii M.

Студент 6 курса педиатрического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: jenya8634@yandex.ru

6th-year student, Faculty of Pediatrics, Rostov State Medical University.

e-mail: jenya8634@yandex.ru

jenya8634@yandex.ruhttps://orcid.org/0009-0006-9718-0221МихайличенкоАнастасия НиколаевнаMikhailichenkoAnastasia N.

Студент 6 курса лечебно-профилактического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: nk_izv@mail.ru

6th-year student, Faculty of General Medicine (Preventive Care), Rostov State Medical University.

e-mail: nk_izv@mail.ru

nk_izv@mail.ruhttps://orcid.org/0009-0007-3240-6442ДенисовАртём ВикторовичDenisovArtem V.

Студент 6 курса лечебно-профилактического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: artem03033@gmail.com

6th-year student, Faculty of General Medicine (Preventive Care), Rostov State Medical University.

e-mail: artem03033@gmail.com

artem03033@gmail.comhttps://orcid.org/0009-0005-3689-141XГостеваЕлена СергеевнаGostevaElena S.

Студент 6 курса лечебно-профилактического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: eleni.gostewa@yandex.ru

6th-year student, Faculty of General Medicine (Preventive Care), Rostov State Medical University.

e-mail: eleni.gostewa@yandex.ru

eleni.gostewa@yandex.ruhttps://orcid.org/0009-0009-1372-5768ХамаянВиктория БорисовнаKhamayanViktoria B.

Студент 6 курса педиатрического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: B.VikaVika7@mail.ru

6th-year student, Faculty of Pediatrics, Rostov State Medical University.

e-mail: B.VikaVika7@mail.ru

B.VikaVika7@mail.ruhttps://orcid.org/0009-0008-2653-8008ЧижиковМаксим РомановичChizhikovMaksim R.

Судент 6 курса лечебно-профилактического факультета, ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.

e-mail: cizicov@mail.ru

6th-year student, Faculty of General Medicine (Preventive Care), Rostov State Medical University.

e-mail: cizicov@mail.ru

cizicov@mail.ruМБУЗ «Городская поликлиника № 10»РоссияCity Polyclinic No. 10Russian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian Federation202627032026662123132Copyright © Солощенко А.Е., Соколова Е.А., Максутова М.В., Бислиева М.Р., Волосеко А.П., Цаплин Е.М., Михайличенко А.Н., Денисов А.В., Гостева Е.С., Хамаян В.Б., Чижиков М.Р., 20262026Солощенко А.Е., Соколова Е.А., Максутова М.В., Бислиева М.Р., Волосеко А.П., Цаплин Е.М., Михайличенко А.Н., Денисов А.В., Гостева Е.С., Хамаян В.Б., Чижиков М.Р.Soloshchenko A.E., Sokolova E.A., Maksutova M.V., Bislieva M.R., Voloseko A.P., Tsaplin E.M., Mikhailichenko A.N., Denisov A.V., Gosteva E.S., Khamayan V.B., Chizhikov M.R.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/4089

Профессиональная бронхиальная астма — одна из наиболее значимых форм заболеваний органов дыхания, связанных с трудовой деятельностью, и характеризуется существенным социально-экономическим ущербом, сложностями диагностики и нередко — тяжёлым, в том числе стероидрезистентным течением. Цель обзора — обобщить современные сведения о распространённости и ведущих причинных факторах профессиональной астмы, а также систематизировать данные о роли аутофагии в её патогенезе и терапевтическом потенциале модуляции аутофагических путей. Выполнен анализ публикаций, посвящённых сенсибилизаторам высокой и низкой молекулярной массы, с акцентом на экспериментальные модели и клеточные системы, которые в настоящее время формируют основную доказательную базу. Показано, что профессиональные аллергены способны вызывать клеточно-специфические нарушения аутофагии в эпителиальных, гладкомышечных и дендритных клетках, что сопряжено с окислительным стрессом, активацией воспалительных каскадов, гиперсекрецией слизи, ремоделированием дыхательных путей и вариантами программируемой гибели клеток. Наиболее изученные механизмы касаются HMW-сенсибилизаторов, тогда как для LMW-агентов данные ограничены, несмотря на их связь с более частыми тяжёлыми обострениями и меньшей чувствительностью к стандартной противовоспалительной терапии.

Участие авторов

Участие авторов:Солощенко А.Е. — концепция и дизайн исследования, координация работы, критическое редактирование рукописи;Соколова Е.А. — поиск и анализ литературы, написание текста статьи;Максутова М.В. — поиск и анализ литературных источников, написание текста статьи;Бислиева М.Р. — поиск литературы, систематизация данных, участие в написании текста;Волосеко А.П. — обзор и аналитическая обработка опубликованных данных;Цаплин Е.М. — анализ литературных источников, участие в написании текста;Михайличенко А.Н. — поиск и анализ литературы, редактирование текста статьи;Денисов А.В. — поиск литературы, анализ данных, написание текста статьи;Гостева Е.С. — анализ и интерпретация опубликованных данных, редактирование рукописи;Хамаян В.Б. — поиск литературы, участие в написании текста статьи;Чижиков М.Р. — анализ и систематизация литературных данных, критическое редактирование рукописи;Все авторы — одобрение окончательной версии рукописи, ответственность за все аспекты работы.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Конфликт интересов

Конфликт интересов. Автор заявляет об отсутствии конфликта интересов.

Дата поступления

Дата поступления: 03.02.2026 / Дата принятия к печати: 12.02.2026 / Дата публикации: 27.03.2026

Occupational bronchial asthma is one of the most significant forms of respiratory diseases associated with work, and is characterized by significant socio-economic damage, diagnostic difficulties, and often severe, including steroid-resistant course. The study aims to summarize current information on the prevalence and leading causative factors of occupational asthma, as well as to systematize data on the role of autophagy in its pathogenesis and the therapeutic potential of autophagic pathway modulation. The authors conducted an analysis of publications on sensitizers with high and low molecular weight, with an emphasis on experimental models and cellular systems that currently form the main evidence base. The occupational allergens are capable of causing cell-specific disorders of autophagy in epithelial, smooth muscle, and dendritic cells, which is associated with oxidative stress, activation of inflammatory cascades, mucus hypersecretion, airway remodeling, and variants of programmed cell death. The most studied mechanisms are associated with HMW sensitizers, whereas data are limited for LMW agents, despite their association with more frequent severe exacerbations and lower sensitivity to standard anti-inflammatory therapy.

The most studied mechanisms are related to HMW sensitizers, while data for LMW agents are limited, despite their association with more frequent severe exacerbations and lower sensitivity to standard anti-inflammatory therapy.

Contributions

Contributions:Soloshchenko A.E. — research concept and design, coordination of work, critical editing of the manuscript;Sokolova E.A. — search and analysis of literature, writing the text of the article;Maksutova M.V. — search and analysis of literary sources, writing the text of the article;Bislieva M.R. — literature search, data systematization, participation in writing the text;Voloseko A.P. — review and analytical processing of published data;Tsaplin E.M. — analysis of literary sources, participation in writing the text;Mikhaylichenko A.N. — search and analysis of literature, editing of the text of the article;Denisov A.V. — literature search, data analysis, writing the text of the article;Gosteva E.S. — analysis and interpretation of published data, editing of the manuscript;Khamayan V.B. — literature search, participation in writing the text of the article;Chizhikov M.R. — analysis and systematization of literary data, critical editing of the manuscript;All authors — approving the final version of the manuscript and for all aspects of the work.

Funding

Funding. The study had no funding.

Conflict of interest

Conflict of interest. The author declares no conflict of interest.

Received

Received: 03.02.2026 / Accepted: 12.02.2026 / Published: 27.03.2026

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The authors declare that there are no conflicts of interest present.