zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2025-65-11-722-727buktmxzurniimtpe-3988Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSНарушение микробиома кожи как ключевой фактор в развитии профдерматозовViolation of the skin microbiome as a key factor in the development of occupational dermatoseshttps://orcid.org/0000-0002-7053-568XИзмероваНаталья ИвановнаIzmerovaNatalya I.

Главный научный сотрудник, Заслуженный врач РФ, д-р мед. наук, проф.

e-mail: izmerova@irioh.ru

Chief Researcher, Honored Doctor of the Russian Federation, Dr. of Sci. (Med.), Professor.

e-mail: izmerova@irioh.ru

izmerova@irioh.ruhttps://orcid.org/0000-0003-3186-8024КузьминаЛюдмила ПавловнаKuzminaLyudmila P.

Зам. дир. по научной работе, д-р биол. наук, профессор.

e-mail: kuzmina@irioh.ru

Deputy Director for Scientific Work, Dr. of Sci. (Biol.), Professor.

e-mail: kuzmina@irioh.ru

kuzmina@irioh.ruЧистоваИлона ЯрославовнаChistovaIlona Ya.

Ст. науч. сотр. клинического отдела профессиональных и производственно обусловленных заболеваний, канд. мед. наук.

e-mail: ilonachis@mail.ru

Senior Researcher of the Clinical Department of Occupational and Work-related Diseases, Cand. of Sci. (Med.).

e-mail: ilonachis@mail.ru

ilonachis@mail.ruФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова»РоссияIzmerov Research Institute of Occupational HealthRussian Federation2025101220256511722727Copyright © Измерова Н.И., Кузьмина Л.П., Чистова И.Я., 20252025Измерова Н.И., Кузьмина Л.П., Чистова И.Я.Izmerova N.I., Kuzmina L.P., Chistova I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/3988

Профессиональные заболевания, в частности дерматозы, традиционно связывают с воздействием на кожу химических и физических факторов производственной среды. В последние годы появились научные данные, свидетельствующие о том, что ключевым патогенетическим звеном в развитии и персистенции профессиональных дерматозов является нарушение микробиома кожи. Кожный микробиом представляет собой сложное полимикробное сообщество, играющее важную роль в поддержании гомеостаза и барьерных функций кожи. Появляется всё больше доказательств, указывающих на роль дисбиоза микробиоты в патогенезе различных дерматологических заболеваний.

В аналитическом обзоре представлены данные зарубежных и отечественных исследований о роли дисбиоза в развитии заболеваний кожи, индуцированных производственными факторами.

Научные данные чётко указывают, что условия труда в различных профессиях формируют специфический микробиом кожи работников. Различная профессиональная деятельность выступает в роли мощного фактора, который избирательно подавляет одни таксоны микроорганизмов и способствует пролиферации других, формирует уникальный микробиом кожи.

Понимание механизмов взаимодействия микроорганизмов кожи с иммунной системой открывает новые перспективы для разработки профилактических и терапевтических стратегий, направленных на восстановление здорового микробиома при дерматозах различного генеза.

Выявление дисбиоза, ассоциированного с повышенным риском развития профессиональных дерматозов, как биомаркера, имеет фундаментальное и практическое значение для превентивной медицины. Персонализированный подход позволит внедрить адресные средства защиты, направленных на коррекцию именно тех дисбиотических сдвигов, которые характерны для конкретной профессии.

Участие авторов

Участие авторов:Измерова Н.И. — концепция и дизайн, сбор и обработка данных, написание текста, редактирование;Кузьмина Л.П. — концепция и дизайн, написание текста, редактирование;Чистова И.Я. — сбор и обработка данных, написание текста.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов

Дата поступления

Дата поступления: 11.11.2025 / Дата принятия к печати: 11.13.2025 / Дата публикации: 10.12.2025

Occupational diseases, in particular dermatoses, are traditionally associated with exposure to the skin of chemical and physical factors of the industrial environment. In recent years, scientific evidence has emerged indicating that a key pathogenetic link in the development and persistence of occupational dermatoses is a violation of the skin microbiome.

The skin microbiome is a complex polymicrobial community that plays an important role in maintaining skin homeostasis and barrier functions. There is increasing evidence pointing to the role of microbiota dysbiosis in the pathogenesis of various dermatological diseases. The analytical review presents data from foreign and domestic studies on the role of dysbiosis in the development of skin diseases induced by occupational factors.

Scientific evidence clearly indicates that working conditions in various professions shape the specific microbiome of workers' skin. Various professional activities act as a powerful factor that selectively suppresses some taxa of microorganisms and promotes the proliferation of others, forming a unique microbiome of the skin.

Understanding the mechanisms of interaction of skin microorganisms with the immune system opens up new prospects for the development of preventive and therapeutic strategies aimed at restoring a healthy microbiome in dermatoses of various origins.

The identification of dysbiosis associated with an increased risk of developing occupational dermatoses as a biomarker is of fundamental and practical importance for preventive medicine. A personalized approach will allow the introduction of targeted protective measures aimed at correcting precisely those dysbiotic shifts that are characteristic of a particular profession.

Contributions

Contributions:Izmerova N.I. — concept and design, data collection and processing, text writing, editing;Kuzmina L.P. — concept and design, writing, editing;Chistova I.Ya. — data collection and processing, writing text.

Funding

Funding. The study had no funding.

Conflict of interests

Conflict of interests. The authors declare no conflict of interest.

Received

Received: 11.11.2025 / Accepted: 13.11.2025 / Published: 10.12.2025

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The authors declare that there are no conflicts of interest present.