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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zurniimtpe</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина труда и промышленная экология</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Occupational Health and Industrial Ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1026-9428</issn><issn pub-type="epub">2618-8945</issn><publisher><publisher-name>FSBSI “Izmerov Research Institute of Occupational Health”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31089/1026-9428-2024-64-11-722-729</article-id><article-id custom-type="edn" pub-id-type="custom">vohtlm</article-id><article-id custom-type="elpub" pub-id-type="custom">zurniimtpe-3610</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Гигиеническая оценка потенциальной опасности воздействия мелкодисперсных частиц и редкоземельных элементов, присутствующих в воздухе рабочей зоны, на работников металлургических предприятий</article-title><trans-title-group xml:lang="en"><trans-title>Hygienic assessment of the potential danger of exposure to fine particles and rare earth elements present in the workplace air for workers at metallurgical enterprises</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2356-1145</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцева</surname><given-names>Нина Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Zaitseva</surname><given-names>Nina V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Научный руководитель, академик РАН, д-р мед. наук, профессор</p><p>e-mail: root@fcrisk.ru</p></bio><bio xml:lang="en"><p>Scientific Director, Academician of the Russian Academy of Sciences, Dr. of Sci. (Med.), Professor</p><p>e-mail: root@fcrisk.ru</p></bio><email xlink:type="simple">root@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2344-3037</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нурисламова</surname><given-names>Татьяна Валентиновна</given-names></name><name name-style="western" xml:lang="en"><surname>Nurislamova</surname><given-names>Tatyana V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заведующий отделом, д-р биол. наук, доцент</p><p>e-mail: nurtat@fcrisk.ru</p></bio><bio xml:lang="en"><p>Head of Department, Dr. of Sci. (Biol.), Docent</p><p>e-mail: nurtat@fcrisk.ru</p></bio><email xlink:type="simple">nurtat@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4276-9921</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зорина</surname><given-names>Анастасия Сергеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Zorina</surname><given-names>Anastasia S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заведующий лабораторией, канд. биол. наук</p><p>e-mail: zorina@fcrisk.ru</p></bio><bio xml:lang="en"><p>Head of the Laboratory, Cand. of Sci. (Biol.</p><p>e-mail: zorina@fcrisk.ru</p></bio><email xlink:type="simple">zorina@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5772-2379</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стенно</surname><given-names>Елена Вячеславовна</given-names></name><name name-style="western" xml:lang="en"><surname>Stenno</surname><given-names>Elena V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заведующий лабораторией</p><p>e-mail: steno@fcrisk.ru</p></bio><bio xml:lang="en"><p>Head of the Laboratory</p><p>e-mail: steno@fcrisk.ru</p></bio><email xlink:type="simple">steno@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8931-0539</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>Алексей Александрович</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>Aleksey A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Младший научный сотрудник</p><p>e-mail: Krylov@fcrisk.ru</p></bio><bio xml:lang="en"><p>Junior Researcher</p><p>e-mail: Krylov@fcrisk.ru</p></bio><email xlink:type="simple">Krylov@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6514-7239</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недошитова</surname><given-names>Анна Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Nedoshitova</surname><given-names>Anna V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старший научный сотрудник</p><p>e-mail: nav@fcrisk.ru</p></bio><bio xml:lang="en"><p>Senior Researcher</p><p>e-mail: nav@fcrisk.ru</p></bio><email xlink:type="simple">nav@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6898-3646</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гилева</surname><given-names>Ксения Олеговна</given-names></name><name name-style="western" xml:lang="en"><surname>Gileva</surname><given-names>Ksenia О.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Научный сотрудник, канд. хим. наук</p><p>e-mail: ksenimanilova@mail.ru</p></bio><bio xml:lang="en"><p>Researcher, Cand. of Sci. (Chem.)</p><p>e-mail: ksenimanilova@mail.ru</p></bio><email xlink:type="simple">ksenimanilova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3787-6746</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухих</surname><given-names>Екатерина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhikh</surname><given-names>Ekaterina А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Младший научный сотрудник</p><p>e-mail: suhih@fcrisk.ru</p></bio><bio xml:lang="en"><p>Junior Researcher</p><p>e-mail: suhih@fcrisk.ru</p></bio><email xlink:type="simple">suhih@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Scientific Center for Medical and Preventive Health Risk Management Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2024</year></pub-date><volume>64</volume><issue>11</issue><fpage>722</fpage><lpage>729</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зайцева Н.В., Нурисламова Т.В., Зорина А.С., Стенно Е.В., Крылов А.А., Недошитова А.В., Гилева К.О., Сухих Е.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Зайцева Н.В., Нурисламова Т.В., Зорина А.С., Стенно Е.В., Крылов А.А., Недошитова А.В., Гилева К.О., Сухих Е.А.</copyright-holder><copyright-holder xml:lang="en">Zaitseva N.V., Nurislamova T.V., Zorina A.S., Stenno E.V., Krylov A.A., Nedoshitova A.V., Gileva K.О., Sukhikh E.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.journal-irioh.ru/jour/article/view/3610">https://www.journal-irioh.ru/jour/article/view/3610</self-uri><abstract><sec><title>Введение</title><p>Введение. Одним из основных загрязнителей воздуха рабочей зоны предприятий металлургической промышленности являются редкоземельные элементы, которые сорбируются на мелкодисперсных частицах пыли и оказывают негативное влияние на здоровье работников.</p><p>Цель исследования — комплексная гигиеническая оценка потенциальной опасности для здоровья работающих мелкодисперсных частиц и редкоземельных элементов (РЗЭ) воздуха рабочей зоны предприятий металлургической промышленности.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведён отбор проб воздуха рабочей зоны для измерения содержания РЗЭ, пыли и промышленного аэрозоля мелкодисперсных фракций. Оценены уровни содержания РЗЭ в крови работников металлургического предприятия (n=31) и группы сравнения (n=12). Измерение содержания РЗЭ в воздухе рабочей зоны и крови проводили методом масс-спектрометрии с индуктивно-связанной плазмой с помощью масс-спектрометра Agilent 7900. Измерение содержания пыли в воздухе рабочей зоны определяли в соответствии с методикой МУК 4.1.2468-09. Определение содержания мелкодисперсных фракций промышленного аэрозоля — анализатором аэрозоля DustTrak 8533.</p></sec><sec><title>Результаты</title><p>Результаты. Анализ содержания металлов в воздухе рабочей зоны показал превышение референтных концентраций при хроническом ингаляционном воздействии для церия. В точках с высокими концентрациями металлов преобладает содержание промышленного аэрозоля мелкодисперсной фракции 10 мкм. В период исследования воздуха рабочей зоны были установлены достоверно более высокие концентрации в крови у работников, занятых на производстве, по сравнению с группой сравнения.</p></sec><sec><title>Ограничения исследования</title><p>Ограничения исследования. Ограничение исследований связано с периодом отбора проб воздуха рабочей зоны, недостаточным количеством проб воздуха рабочей зоны и проб биоматериала. Расширение перечня обследуемых точек на производстве и списка металлургических предприятий, а также увеличение количества обследуемых работников может стать направлением дальнейших исследований по оценке воздействия мелкодисперсных частиц и редкоземельных элементов на работников металлургических предприятий.</p></sec><sec><title>Заключение</title><p>Заключение. Поскольку в воздухе рабочей зоны и в крови работников были обнаружены более высокие концентрации РЗЭ по сравнению с контрольной точкой / группой, сокращение воздействия вредных производственных факторов условий труда и производственных процессов с целью сохранения здоровья работающих остаётся актуальным для предприятий металлургической промышленности.</p></sec><sec><title>Этика</title><p>Этика. Исследование проведено с соблюдением этических норм согласно этическим принципам, изложенными в Хельсинкской декларации Всемирной медицинской ассоциации (ред. 2013 г.). Исследование одобрено локальным этическим комитетом ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Роспотребнадзора (протокол заседания № 2 от 11.02.2021 г.).</p></sec><sec><title>Участие авторов</title><p>Участие авторов:Зайцева Н.В. — концепция и дизайн исследования, редактирование;Нурисламова Т.В. — концепция и дизайн исследования, редактирование;Зорина А.С. — концепция и дизайн исследования, сбор материала и обработка данных, написание текста;Стенно Е.В. — концепция и дизайн исследования, редактирование;Крылов А.А. — сбор материала и обработка данных;Недошитова А.В. — сбор материала и обработка данных;Гилева К.О. — сбор материала и обработка данных;Сухих Е.А. — сбор материала и обработка данных.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование не имело финансовой поддержки.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.</p></sec><sec><title>Дата поступления</title><p>Дата поступления: 02.10.2024 / Дата принятия к печати: 03.11.2024 / Дата публикации: 27.11.2024</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. One of the main air pollutants in the working area of metallurgical enterprises is rare earth elements, which are sorbed on fine dust particles and have a negative impact on the health of workers.</p><p>The study aims to carry out a comprehensive hygienic assessment of the potential health hazards of fine particles and rare earth elements (REE) contained in the air of the working area at metallurgical enterprises.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The specialists have took samples of the working area air to measure the content of REE, dust and industrial aerosol of small fractions, they have assessed the levels of REE in the blood of employees of the metallurgical enterprise (n=31) and the comparison group (n=12). The scientists have measured the REE content in the air of the working area and blood using inductively coupled plasma mass spectrometry on an Agilent 7900 mass spectrometer. The authors have measured the dust content in the air of the working area in accordance with the MUK 4.1.2468-09 method and determined the content of fine fractions of industrial aerosol using the DustTrak 8533 aerosol analyzer.</p></sec><sec><title>Results</title><p>Results. Analysis of the metal content in the air of the working area showed an excess of control concentrations for chronic inhalation exposure to cerium. In points with a high concentration of metals, the content of industrial aerosol of a fine fraction of 10 microns prevails. During the study of the work area, experts found significantly higher concentrations in the blood of workers employed in production, compared with the comparison group.</p></sec><sec><title>Limitations</title><p>Limitations. The limitation of research is due to the period of sampling of the working area air, insufficient number of samples of the working area air and samples of biomaterial. The expansion of the list of surveyed points in production and the list of metallurgical enterprises, as well as an increase in the number of surveyed workers, may become a direction for further research to assess the impact of fine particles and rare earth elements on workers of metallurgical enterprises.</p></sec><sec><title>Conclusion</title><p>Conclusion. Since higher concentrations of REE were found in the air of the work area and in the blood of workers compared to the control point/group, reducing the impact of harmful production factors of working conditions and production processes in order to preserve the health of workers remains relevant for enterprises of the metallurgical industry.</p></sec><sec><title>Ethics</title><p>Ethics. The study was conducted in compliance with Ethical standards in accordance with the Ethical principles set out in the Helsinki Declaration of the World Medical Association (ed. 2013). The study was approved by the local Ethical Committee of the Federal Scientific Center for Medical and Preventive Technologies for Public Health Risk Management of Rospotrebnadzor (meeting protocol No. 2 dated 02/11/2021).</p></sec><sec><title>Contribution</title><p>Contribution:Zaitseva N.V. — concept and design of the study, editing;Nurislamova T.V. — concept and design of the study, editing;Zorina A.S. — research concept and design, material collection and data processing, text writing;Stenno E.V. — concept and design of the study, editing;Krylov A.A. — material collection and data processing;Nedoshitova A.V. — material collection and data processing;Gileva K.O. — material collection and data processing;Sukhikh E.A. — material collection and data processing.</p></sec><sec><title>Funding</title><p>Funding. The study had no funding.</p></sec><sec><title>Conflict of interests</title><p>Conflict of interests. The authors declare no conflicts of interests.</p></sec><sec><title>Received</title><p>Received: 02.10.2024 / Accepted: 03.11.2024 / Published: 27.11.2024</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>воздух рабочей зоны</kwd><kwd>мелкодисперсные частицы</kwd><kwd>редкоземельные металлы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>air of the working area</kwd><kwd>fine particles</kwd><kwd>rare earth metals</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cai A., Zhang H., Wang Q., Wu X. Source apportionment and health risk assessment of heavy metals in PM2.5 in Handan: A typical heavily polluted city in North China. Atmosphere. 2021; 12(10): 1232. https://doi.org/10.3390/atmos12101232</mixed-citation><mixed-citation xml:lang="en">Cai A., Zhang H., Wang Q., Wu X. 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