zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2023-63-11-723-729rvbwtczurniimtpe-3332Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWОднонуклеотидные полиморфизмы генов (SNP) как маркеры повышенного риска развития нарушений здоровья, связанных с воздействием производственного шумаSingle nucleotide gene polymorphisms (SNPs) as markers of the increased risk of health disorders associated with exposure to industrial noisehttps://orcid.org/0000-0002-8220-145XМазиловСвятослав ИгоревичMazilovSvyatoslav I.

Младший научный сотрудник, Саратовский медицинский научный центр гигиены ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Роспотребнадзора, канд. биол. наук

e-mail: smazilov@yandex.ru

Junior researcher, Saratov Medical Scientific Center of Hygiene of the Federal Scientific Center for Medical and Preventive Technologies of Public Health Risk Management, Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Cand. of Sci. (Biol.)

e-mail: smazilov@yandex.ru

 

smazilov@yandex.ruhttps://orcid.org/0000-0003-4099-9368КомлеваНаталья Е.KomlevaNataliia E.noemail@neicon.ruhttps://orcid.org/0000-0003-1463-0559НовиковаТамара А.NovikovaTamara A.noemail@neicon.ruСаратовский медицинский научный центр гигиены ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» РоспотребнадзораРоссияSaratov Hygiene Medical Research Center of the «Federal Scientific Center for Medical and Preventive Technologies for Public Health Risk Management»Russian FederationСаратовский медицинский научный центр гигиены ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Роспотребнадзора; ФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» Минздрава РоссииРоссияSaratov Hygiene Medical Research Center of the «Federal Scientific Center for Medical and Preventive Technologies for Public Health Risk Management»; Saratov State Medical University n.a. V.I. RazumovskyRussian Federation2023151220236311723729Copyright © Мазилов С.И., Комлева Н.Е., Новикова Т.А., 20232023Мазилов С.И., Комлева Н.Е., Новикова Т.А.Mazilov S.I., Komleva N.E., Novikova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/3332

Известно, что одни и те же факторы окружающей среды, включая производственную, при одинаковой интенсивности воздействия могут вызывать различные ответные реакции организма человека в зависимости от его индивидуальных особенностей, которые определяются в том числе наличием и комбинацией однонуклеотидных полиморфизмов генов, ответственных за специфичность ответной реакции организма человека на воздействия стресс-факторов, что обусловливает важность их изучения в плане профилактики нарушений здоровья населения.

На основе обобщения и систематизации современного отечественного и зарубежного опыта рассмотрено использование однонуклеотидных полиморфизмов генов в качестве маркеров повышенного риска развития нарушений здоровья, связанных с воздействием шума на рабочем месте.

Определён перечень конкретных однонуклеотидных полиморфизмов генов, наличие которых может влиять на развитие нарушений здоровья в условиях шумового воздействия.

Показано, что использование генетических маркеров для оценки индивидуального риска нарушений здоровья лиц, работающих в условиях воздействия производственного шума, будет способствовать развитию персонифицированной медицины и своевременной профилактике профессиональных и общих заболеваний, связанных с воздействием вредных условиях труда. Для обзора были отобраны публикации, посвящённые исследованиям ответа организма на производственный шум, с доступом к полному тексту.

Этика

Этика. Данное исследование не требовало заключения этического комитета.

Участие авторов

Участие авторов:Мазилов С.И. — концепция и дизайн исследования, сбор и обработка данных, написание текста, редактирование;Комлева Н.Е. — концепция и дизайн исследования, написание текста, редактирование;Новикова Т.А. — сбор и обработка данных, редактирование.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Дата поступления

Дата поступления: 10.08.2023 / Дата принятия к печати: 24.10.2023 / Дата публикации: 15.12.2023

It is known that the same environmental factors, including industrial ones, with the same intensity of exposure can cause different responses of the human body depending on its individual characteristics, which are determined, inter alia, by the presence and combination of single-nucleotide polymorphisms of genes responsible for the specificity of the human body's response to stress factors, which causes the importance of their study from the point of view of prevention of public health disorders.

Based on the generalization and systematization of modern domestic and foreign experience, the authors have examined the use of single-nucleotide polymorphisms of genes as markers of increased risk of health disorders associated with exposure to noise in the workplace.

Scientists have identified a list of specific single-nucleotide polymorphisms of genes, the presence of which can affect the development of health disorders when exposed to noise.

It is shown that the use of genetic markers to assess the individual risk of health disorders of persons working under the influence of industrial noise will contribute to the development of personalized medicine and timely prevention of occupational and general diseases associated with exposure to harmful working conditions. The authors have selected for review publications devoted to studies of the body's response to industrial noise, with access to the full text.

Ethics

Ethics. This study did not require the conclusion of the Ethics Committee.

Contribution

Contribution:Mazilov S.I. — research concept and design, data collection and processing, the text writing, editing;Komleva N.E. — research concept and design, the text writing, editing;Novikova T.A. — data collection and processing, editing.

Funding

Funding. The study had no funding.

Conflict of interests

Conflict of interests. The authors declare no conflict of interests.

Received

Received: 10.08.2023 / Accepted: 24.10.2023 /Published: 15.12.2023

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The authors declare that there are no conflicts of interest present.