zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2023-63-11-694-701hansaxzurniimtpe-3328Research ArticleСтатьиВлияние физических производственных факторов на иммунную системуThe influence of physical occupational factors on the immune systemhttps://orcid.org/0000-0003-3186-8024КузьминаЛюдмила П.KuzminaLyudmila P.noemail@neicon.ruhttps://orcid.org/0000-0002-7053-568XИзмероваНаталья И.IzmerovaNatalia I.noemail@neicon.ruhttps://orcid.org/0000-0003-0359-1785ХотулеваАнастасия ГригорьевнаKhotulevaAnastasia G.

Ст. науч. сотр. лаб. медико-биологических исследований ФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова», канд. мед. наук

e-mail: hotuleva_an@mail.ru

The senior researcher аt the Laboratory of Biomedical Research, Izmerov Research Institute of Occupational Health, Cand. of Sci. (Med.)

e-mail: hotuleva_an@mail.ru

hotuleva_an@mail.ruhttps://orcid.org/0000-0003-2974-775XЦидильковскаяЭльвира С.TsidilkovskayaElvira S.noemail@neicon.ruhttps://orcid.org/0000-0002-7024-6634КисляковаАгата А.KisljakovaAgata A.noemail@neicon.ruhttps://orcid.org/0000-0001-7574-343XМилиХайтемMiliHaithemnoemail@neicon.ruФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияIzmerov Research Institute of Occupational Health; I.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова»РоссияIzmerov Research Institute of Occupational HealthRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation2023151220236311694701Copyright © Кузьмина Л.П., Измерова Н.И., Хотулева А.Г., Цидильковская Э.С., Кислякова А.А., Мили Х., 20232023Кузьмина Л.П., Измерова Н.И., Хотулева А.Г., Цидильковская Э.С., Кислякова А.А., Мили Х.Kuzmina L.P., Izmerova N.I., Khotuleva A.G., Tsidilkovskaya E.S., Kisljakova A.A., Mili H.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/3328

Факторы окружающей среды могут оказывать влияние на различные звенья иммунитета, потенцируя формирование иммунопатологических процессов, лежащих в основе развития большой группы заболеваний.

Цель исследования — анализ результатов экспериментальных и наблюдательных исследований по оценке влияния шума, вибрации, ЭМП на иммунологические показатели.

Среди механизмов воздействия физических факторов на иммунную систему большинство авторов выделяют действие через нейроэндокринную систему и потенцирование окислительного стресса.

Экспериментальные исследования на лабораторных животных по оценке воздействия шума на иммунную систему демонстрируют влияние шума на показатели клеточного и гуморального иммунитета, интенсивность аллергической реакции, чувствительность к инфекционным агентам.

Результаты обследований работников, подвергающихся воздействию производственной вибрации, свидетельствуют о влияние этого производственного фактора на гуморальный, клеточный иммунитет, цитокиновый статус, однако выявляемые изменения данных иммунологических показателей могут быть разнонаправленными.

Экспериментальные исследования in vitro свидетельствуют, что после воздействия ЭМП на иммунные клетки в них выявляются многочисленные изменения. Имеются исследования, демонстрирующие изменение показателей иммунной системы у лиц, подвергающихся воздействию ЭМП.

Таким образом, анализ литературных источников свидетельствует о влиянии физических производственных факторов (шум, вибрация, ЭМП) на иммунный статус организма, что определяет перспективность исследований, направленных на разработку критериев оценки изменений иммунологических показателей для выделения групп повышенного риска развития патологии.

Вклад авторов

Вклад авторов:Кузьмина Л.П. — концепция и дизайн обзора, редактирование;Измерова Н.И. — концепция и дизайн обзора, редактирование;Хотулева А.Г. — сбор, обработка материала и написание текста;Цидильковская Э.С. — сбор, обработка материала и написание текста;Кислякова А.А. — сбор, обработка материала;Мили Х. — сбор материала.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Конфликт интересов

Конфликт интересов. Авторы статьи сообщают об отсутствии конфликта интересов.

Дата поступления

Дата поступления: 28.11.2023 / Дата принятия к печати: 01.12.2023 / Дата публикации: 15.12.2023

Environmental factors can influence various parts of the immune system, potentiating the formation of immunopathological processes underlying the development of a large group of diseases.

The study aims to analyze the results of experimental and observational studies to assess the effect of noise, vibration, and electromagnetic fields (EMF) on immunological parameters.

Among the mechanisms of the influence of physical factors on the immune system, most authors single out the action through the neuroendocrine system and the potentiation of oxidative stress.

Experimental studies on laboratory animals to assess the effects of noise on the immune system demonstrate the effect of noise on cellular and humoral immunity, the intensity of an allergic reaction, and sensitivity to infectious agents.

The results of surveys of workers exposed to industrial vibration indicate the influence of this production factor on humoral, cellular immunity, and cytokine status, however, the detected changes in these immunological parameters may be multidirectional.

In vitro experimental studies indicate that after exposure to EMF on immune cells, numerous changes are detected in them. There are studies demonstrating changes in the immune system in people exposed to EMF.

Thus, the analysis of literary sources indicates the influence of physical production factors (noise, vibration, EMF) on the immune status of the body, which determines the prospects of research aimed at developing criteria for evaluating changes in immunological parameters to identify groups at increased risk of developing pathology.

Contribution

Contribution:Kuzmina L.P. — concept and design of the review, editing;Izmerova N.I. — concept and design of the review, editing;Khotuleva A.G. — collection, processing of material and writing the text;Tsidilkovskaya E.S. — collection, processing of material and writing the text;Kislyakova A.A. — collection, processing of material;Mili H. — collecting material.

Funding

Funding. The study had no funding.

Conflict of interests

Conflict of interests. The authors declare no conflict of interests.

Received

Received: 28.11.2023 / Accepted: 01.12.2023 / Published: 15.12.2023

шумвибрацияэлектромагнитные поляиммунный статуслимфоцитыиммуноглобулиныцитокиныnoisevibrationelectromagnetic fieldsimmune statuslymphocytesimmunoglobulinscytokinesReferencesЖигулина В.В. Биохимический ответ на стресс (обзор литературы). Тверской медицинский журнал. 2015; 1: 91–100.Zhigulina V.V. Biochemical response to stress (overview). Tverskoj medicinskij zhurnal. 2015; 1: 91–100. (in Russian).Чепель Э., Хейни М., Мисхах С. Основы клинической иммунологии. М.: ГЭОТАР-Медиа; 2008.Chapel H., Haeney М., Misbah S. Essentials of clinical immunology. M.: GEOTAR-Media; 2008 (in Russian).О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2022 году: Государственный доклад. М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2023.On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2022: State report. М.: Federal’naja sluzhba po nadzoru v sfere zashhity prav potrebitelej i blagopoluchija cheloveka, 2023 (in Russian).Курчевенко С.И., Бодиенкова Г.М. Формирование естественной реактивности организма при воздействии производственных физических факторов. XXI век. Техносферная безопасность. 2016; 1(4): 73–78.Kurchevenko S.I., Bodienkova G.M. Formation of natural body reactivity when exposed to industrial physical factors. XXI vek. Tehnosfernaja bezopasnost’. 2016; 1(4): 73–78 (in Russian).Zhang A., Zou T., Guo D., Wang Q., Shen Y., Hu H. et al. The Immune System Can Hear Noise. Front Immunol. 2020; 11: 619189. https://doi.org/10.3389/fimmu.2020.619189Zhang A., Zou T., Guo D., Wang Q., Shen Y., Hu H. et al. The Immune System Can Hear Noise. Front Immunol. 2020; 11: 619189. https://doi.org/10.3389/fimmu.2020.619189Бодиенкова Г.М., Иванская Т.И., Лизарев А. В. Иммунопатогенез вибрационной болезни. Бюллетень ВСНЦ СО РАМН. 2006; 49(3): 72–77.Bodienkova G.M., Ivanskaya T.I., Lizarev A.A. Immunological pathogenesis of vibration-induced disease. Bjulleten’ VSNC SO RAMN. 2006; 49(3): 72–77 (in Russian).Абишева А.А., Белихина Т.И., Казымов М.С., Жунусова Т., Манарбеков Е.М. Многофакторное негативное антропогенное воздействие и система иммунитета у взрослых лиц в г. Усть-Каменогорске. Наука и Здравоохранение. 2021; 4(23): 172–179. https://doi.org/10.34689/SH.2021.23.4.019Abisheva A.A., Belikhina T.I., Kazimov M.S., Zhunusova T., Manarbekov E.M. Multifactorial negative anthropogenic impact and the immune system in adults in Ust-Kamenogorsk. Nauka i Zdravoohranenie. 2021; 4(23): 172–179. https://doi.org/10.34689/SH.2021.23.4.019 (in Russian).Padgett D.A., Glaser R. How stress influences the immune response. Trends Immunol. 2003; 24: 444–448. https://doi.org/10.1016/S1471-4906(03)00173-XPadgett D.A., Glaser R. How stress influences the immune response. Trends Immunol. 2003; 24: 444–448. https://doi.org/10.1016/S1471-4906(03)00173-XGille G., Sigler K. Oxidative stress and living cells. Folia Microbiol (Praha). 1995; 40(2): 131–152 https://doi.org/10.1007/BF02815413Gille G., Sigler K. Oxidative stress and living cells. Folia Microbiol (Praha). 1995; 40(2): 131–152 https://doi.org/10.1007/BF02815413Ising H. Acute and chronic endocrine effects of noise: review of the research conducted at the Institute for Water, Soil and Air Hygiene. Noise and health. 2000; 31(7): 7–24.Ising H. Acute and chronic endocrine effects of noise: review of the research conducted at the Institute for Water, Soil and Air Hygiene. Noise and health. 2000; 31(7): 7–24.Selander J., Bluhm G., Theorell T., Pershagen G., Babisch W., Seiffert I. et al. Saliva cortisol and exposure to aircraft noise in six European countries. Environ. Health Perspect. 2009; 117: 1713–1717. https://doi.org/10.1289/ehp.0900933Selander J., Bluhm G., Theorell T., Pershagen G., Babisch W., Seiffert I. et al. Saliva cortisol and exposure to aircraft noise in six European countries. Environ. Health Perspect. 2009; 117: 1713–1717. https://doi.org/10.1289/ehp.0900933Fouladi D.B., Nassiri P., Monazzam E.M., Farahani S., Hassanzadeh G., Hoseini M. Industrial noise exposure and salivary cortisol in blue collar industrial workers. Noise & Health. 2012; 14(59): 184–189. https://doi.org/10.4103/1463-1741.99894Fouladi D.B., Nassiri P., Monazzam E.M., Farahani S., Hassanzadeh G., Hoseini M. Industrial noise exposure and salivary cortisol in blue collar industrial workers. Noise & Health. 2012; 14(59): 184–189. https://doi.org/10.4103/1463-1741.99894Schmidt F.P., Basner M., Kroger G., Weck S., Schnorbus B., Muttray A. et al. Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults. Eur. Heart J. 2013; 34: 3508–3514. https://doi.org/10.1093/eurheartj/eht269Schmidt F.P., Basner M., Kroger G., Weck S., Schnorbus B., Muttray A. et al. Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults. Eur. Heart J. 2013; 34: 3508–3514. https://doi.org/10.1093/eurheartj/eht269Padgett D.A., Glaser R. How stress influences the immune response. Trends in Immunology. 2003; 24(8): 444–448. https://doi.org/10.1016/s1471-4906(03)00173-xPadgett D.A., Glaser R. How stress influences the immune response. Trends in Immunology. 2003; 24(8): 444–448. https://doi.org/10.1016/s1471-4906(03)00173-xRickard A.J., Young M.J. Corticosteroid receptors, macrophages and cardiovascular disease. Journal of Molecular Endocrinology. 2009; 42(6): 449–459. https://doi.org/10.1677/JME-08-0144Rickard A.J., Young M.J. Corticosteroid receptors, macrophages and cardiovascular disease. Journal of Molecular Endocrinology. 2009; 42(6): 449–459. https://doi.org/10.1677/JME-08-0144Hartono H. Cortisol level decreases natural killer cell activity among women with aircraft noise. Universa Medicina. 2016; 29(3): 153–161. https://doi.org/10.18051/UnivMed.2010.v29.153-161Hartono H. Cortisol level decreases natural killer cell activity among women with aircraft noise. Universa Medicina. 2016; 29(3): 153–161. https://doi.org/10.18051/UnivMed.2010.v29.153-161Imai K., Matsuyama S., Miyake S., Suga K., Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet. 2000; 356(9244): 1795–1799. https://doi.org/10.1016/S0140-6736(00)03231-1Imai K., Matsuyama S., Miyake S., Suga K., Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet. 2000; 356(9244): 1795–1799. https://doi.org/10.1016/S0140-6736(00)03231-1Ljunggren H.G., Malmberg K.J. Prospects for the use of NK cells in immunotherapy of human cancer. Nature Reviews Immunology. 2007; 7(5): 329–339. https://doi.org/10.1038/nri2073Ljunggren H.G., Malmberg K.J. Prospects for the use of NK cells in immunotherapy of human cancer. Nature Reviews Immunology. 2007; 7(5): 329–339. https://doi.org/10.1038/nri2073Вобликов И.В. Оценка роли иммунной системы в развитии нарушений состояния здоровья у лиц, подвергающихся воздействию низкочастотных акустических колебаний в процессе профессиональной деятельности. В кн.: Актуальные проблемы и перспективы развития военной медицины: науч. тр. НИИЦ (МБЗ) ГНИИИВМ МО РФ. СПб., 2000; 2: 55–60.Voblikov I.V. Assessment of the role of the immune system in the development of health disorders in individuals exposed to low-frequency acoustic vibrations during professional activities. In book.: Aktual’nye problemy i perspektivy razvitija voennoj mediciny: nauch. tr. NIIC (MBZ) GNIIIVM MO RF. SPb., 2000; 2: 55–60 (in Russian).Сайфуллин Р.Ф., Селезнев А.Б., Сергеев С.Н., Степанов А.В., Комиссаров Н.В., Гордиенко А.В. Экспериментальная оценка устойчивости организма к инфекционным заболеваниям в условиях воздействия низкочастотного шума. Вестник Российской Военно-медицинской академии. 2017; 1(57): 105–110.Sayfullin R.F., Seleznev A.B., Sergeev S.N., Stepanov A.V., Komissarov N.V., Gordienko A.V. Experimental evaluation of resistance of the organism to infectious diseases in conditions of low-frequency noise. Vestnik Rossijskoj Voenno-medicinskoj akademii. 2017; 1(57): 105–110 (in Russian).Zheng K.C., Ariizumi M. Modulations of immune functions and oxidative status induced by noise stress. J Occup Health. 2007; 49(1): 32–38. https://doi.org/10.1539/joh.49.32Zheng K.C., Ariizumi M. Modulations of immune functions and oxidative status induced by noise stress. J Occup Health. 2007; 49(1): 32–38. https://doi.org/10.1539/joh.49.32Münzel T., Sørensen M., Schmidt F., Schmidt E., Steven S., Kröller-Schön S. et al. The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk. Antioxid Redox Signal. 2018; 28(9): 873–908. https://doi.org/10.1089/ars.2017.7118Münzel T., Sørensen M., Schmidt F., Schmidt E., Steven S., Kröller-Schön S. et al. The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk. Antioxid Redox Signal. 2018; 28(9): 873–908. https://doi.org/10.1089/ars.2017.7118Крючкова Е.Н., Антошина Л.И., Жеглова А.В., Сааркоппель Л.М. Критериальная значимость показателей оксидативного стресса при вибрационном воздействии. Медицина труда и промышленная экология. 2016; 3: 30–34.Kriuchkova E.N., Antoshina L.I., Zheglova A.V., Saarkoppel’ L.M. Criterial value of oxidative stress parameters in exposure to vibration. Medicina truda i promyshlennaja jekologija. 2016; 3: 30–34 (in Russian).Schuermann D., Mevissen M. Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health. Int J Mol Sci. 2021; 22(7): 3772. https://doi.org/10.3390/ijms22073772Schuermann D., Mevissen M. Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health. Int J Mol Sci. 2021; 22(7): 3772. https://doi.org/10.3390/ijms22073772Yang Y., Bazhin A.V., Werner J., Karakhanova S. Reactive oxygen species in the immune system. Int Rev Immunol. 2013; 32(3): 249–270. https://doi.org/10.3109/08830185.2012.755176Yang Y., Bazhin A.V., Werner J., Karakhanova S. Reactive oxygen species in the immune system. Int Rev Immunol. 2013; 32(3): 249–270. https://doi.org/10.3109/08830185.2012.755176Lotze M.T., Zeh H.J., Rubartelli A., Sparvero L.J., Amoscato A.A., Washburn N.R. et al. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunol Rev. 2007; 220: 60–81. https://doi.org/10.1111/j.1600-065X.2007.00579.xLotze M.T., Zeh H.J., Rubartelli A., Sparvero L.J., Amoscato A.A., Washburn N.R. et al. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunol Rev. 2007; 220: 60–81. https://doi.org/10.1111/j.1600-065X.2007.00579.xGill R., Tsung A., Billiar T. Linking oxidative stress to inflammation: toll-like receptors. Free Radic Biol Med. 2010; 48: 1121–1132. https://doi.org/10.1016/j.freeradbiomed.2010.01.006Gill R., Tsung A., Billiar T. Linking oxidative stress to inflammation: toll-like receptors. Free Radic Biol Med. 2010; 48: 1121–1132. https://doi.org/10.1016/j.freeradbiomed.2010.01.006Цейликман В.Э., Лукин А.А. Влияние окислительного стресса на организм человека. Международный научно-исследовательский журнал. 2022; 3(117): 206–211. https://doi.org/10.23670/IRJ.2022.117.3.037Tseylikman V.E., Lukin A.A. On the effect of oxidative stress on the human body. Mezhdunarodnyj nauchno-issledovatel’skij zhurnal. 2022; 3(117): 206–211. https://doi.org/10.23670/IRJ.2022.117.3.037 (in Russian).Casciola-Rosen L., Wigley F., Rosen. A. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. Journal of Experimental Medicine. 1997. 185(1): 71–79. https://doi.org/10.1084/jem.185.1.71Casciola-Rosen L., Wigley F., Rosen. A. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. Journal of Experimental Medicine. 1997. 185(1): 71–79. https://doi.org/10.1084/jem.185.1.71Buttari B., Profumo E., Mattei V., Siracusano A., Ortona E., Margutti P. et al. Oxidized 2-glycoprotein I induces human dendritic cell maturation and promotes a T helper type 1 response. Blood. 2005; 106(12): 3880–3887. https://doi.org/10.1182/blood-2005-03-1201Buttari B., Profumo E., Mattei V., Siracusano A., Ortona E., Margutti P. et al. Oxidized 2-glycoprotein I induces human dendritic cell maturation and promotes a T helper type 1 response. Blood. 2005; 106(12): 3880–3887. https://doi.org/10.1182/blood-2005-03-1201Плужников Н.Н., Владимиров В.Г., Зинкин В.Н., Вобликов И.В., Васильева И.Н., Родионов Г.Г. и др. Исследование некоторых механизмов повреждающих эффектов низкочастотных шумов. Радиационная биология. Радиоэкология. 2001; 41(1): 67–72.Pluzhnikov N.N., Vladimirov V.G., Zinkin V.N., Voblikov I.V., Vasilyeva I.N., Rodionov G.G. et al. The study of certain mechanisms of injurious effects of low-frequency noise. Radiacionnaja biologija. Radiojekologija. 2001; 41(1): 67‒72 (in Russian).Ахметзянов И.М., Редько А.А., Сергеев О.Е. Неспецифическое действие шума на организм: неблагоприятное влияние на здоровье человека и возможные пути профилактики. В кн.: Защита населения от повышенного шумового воздействия: сб. докл. Всеросс. научн.-практ. конф. с междунар. участием. ИННОВА; 2006: 168–173.Akhmetzyanov I.M., Redko А.А., Sergeev О.Е. Nonspecific effects of noise on the body: adverse effects on human health and possible ways of prevention. In book: Zashhita naselenija ot povyshennogo shumovogo vozdejstvija: sb. dokl. Vseross. nauchn.-prakt. konf. s mezhdunar. uchastiem. INNOVA; 2006: 168–173. (in Russian)Recio A., Linares C., Banegas J.R., Dı́az J. Road traffic noise effects on cardiovascular, respiratory, and metabolic health: An integrative model of biological mechanisms. Environ Res. 2016; 146: 359–370. https://doi.org/10.1016/j.envres.2015.12.036Recio A., Linares C., Banegas J.R., Dı́az J. Road traffic noise effects on cardiovascular, respiratory, and metabolic health: An integrative model of biological mechanisms. Environ Res. 2016; 146: 359–370. https://doi.org/10.1016/j.envres.2015.12.036Pascuan C.G., Uran S.L., Gonzalez-Murano M.R., Wald M.R., Guelman L.R., Genaro A.M. Immune alterations induced by chronic noise exposure: comparison with restraint stress in BALB/c and C57Bl/6 mice. J Immunotoxicol. 2014; 11: 78–83. https://doi.org/10.3109/1547691X.2013.800171Pascuan C.G., Uran S.L., Gonzalez-Murano M.R., Wald M.R., Guelman L.R., Genaro A.M. Immune alterations induced by chronic noise exposure: comparison with restraint stress in BALB/c and C57Bl/6 mice. J Immunotoxicol. 2014; 11: 78–83. https://doi.org/10.3109/1547691X.2013.800171Kim A., Sung J.H., Bang J.-H., Cho S.W., Lee J., Sim C.S. Effects of self-reported sensitivity and road-traffic noise levels on the immune system. PloS One. 2017; 12(10): e0187084. https://doi.org/10.1371/journal.pone.0187084Kim A., Sung J.H., Bang J.-H., Cho S.W., Lee J., Sim C.S. Effects of self-reported sensitivity and road-traffic noise levels on the immune system. PloS One. 2017; 12(10): e0187084. https://doi.org/10.1371/journal.pone.0187084Зинкин В.Н., Свидовый В.И., Ахметзянов И.М. Неблагоприятное действие низкочастотных акустических колебаний на органы дыхания. Профилактическая и клиническая медицина. 2011; 3(40): 280–284.Zinkin V.N., Svidovyi V.I., Akhmetzyanov I.M. Adverse effects of low-frequency acoustic vibrations on the respiratory system. Profilakticheskaja i klinicheskaja medicina. 2011; 3(40): 280–284 (in Russian).She X., Gao X., Wang K., Yang H., Ma K., Cui B. et al. Effects of noise and low-concentration carbon monoxide exposure on rat immunity. J. Occup. Health. 2021; 63(1): e12235. https://doi.org/10.1002/1348-9585.12235She X., Gao X., Wang K., Yang H., Ma K., Cui B. et al. Effects of noise and low-concentration carbon monoxide exposure on rat immunity. J. Occup. Health. 2021; 63(1): e12235. https://doi.org/10.1002/1348-9585.12235Angrini M.A., Leslie J.C. Vitamin C attenuates the physiological and behavioural changes induced by long-term exposure to noise. Behav Pharmacol. 2012; 23(2): 119–125. https://doi.org/10.1097/FBP.0b013e32834f9f68Angrini M.A., Leslie J.C. Vitamin C attenuates the physiological and behavioural changes induced by long-term exposure to noise. Behav Pharmacol. 2012; 23(2): 119–125. https://doi.org/10.1097/FBP.0b013e32834f9f68Van Raaij M.T., Oortgiesen M., Timmerman H.H., Dobbe C.J., Van Loveren H. Time-Dependent Differential Changes of Immune Function in Rats Exposed to Chronic Intermittent Noise. Physiol Behav. 1996; 60: 1527–1533. https://doi.org/10.1016/s0031-9384(96)00327-7Van Raaij M.T., Oortgiesen M., Timmerman H.H., Dobbe C.J., Van Loveren H. Time-Dependent Differential Changes of Immune Function in Rats Exposed to Chronic Intermittent Noise. Physiol Behav. 1996; 60: 1527–1533. https://doi.org/10.1016/s0031-9384(96)00327-7Лычёва О.А., Галиев Р.С. Влияние городского шума на особенности развития аллергической реакции немедленного типа. Экология человека. 2012; 4: 11–15.Lycheva O.A., Galiev R.S. Influence of city noise on development of immediate-onset allergy. Jekologija cheloveka. 2012; 4: 11–15 (in Russian).Галиев Р.С., Дробленков А.В., Галиева С.А. Особенности течения аллергии в условиях шума. Медицина и образование. 2020; 2(6): 10–14.Galiev R.S., Droblenkov A.V., Galieva S.A. Structural specific features of the course of allergy in noise conditions. Medicina i obrazovanie. 2020; 2(6): 10–14 (in Russian).Курчевенко С.И., Боклаженко Е.В., Бодиенкова Г.М. Сравнительный анализ иммунного ответа у рабочих при воздействии различных производственных факторов. Гигиена и санитария. 2018; 97(10): 905–909. https://elibrary.ru/yocquhKurchevenko S.I., Boklazhenko E.V., Bodienkova G.M. Comparative analysis of the immune response of workers exposed to various production factors. Gigiena i sanitarija. 2018; 97(10): 905–909. https://elibrary.ru/yocquh (in Russian).Fujioka M., Kanzaki S., Okano H.J., Masuda M., Ogawa K., Okano H. Proinflammatory cytokines expression in noise-induced damaged cochlea. J. Neurosci. Res. 2006; 83(4): 575–583. https://doi.org/10.1002/jnr.20764Fujioka M., Kanzaki S., Okano H.J., Masuda M., Ogawa K., Okano H. Proinflammatory cytokines expression in noise-induced damaged cochlea. J. Neurosci. Res. 2006; 83(4): 575–583. https://doi.org/10.1002/jnr.20764Tan W.J., Thorne P.R., Vlajkovic S.M. Noise-induced cochlear inflammation. World J Otorhinolaryngol. 2013; 3(3): 89–99. https://doi.org/10.5319/wjo.v3.i3.89Tan W.J., Thorne P.R., Vlajkovic S.M. Noise-induced cochlear inflammation. World J Otorhinolaryngol. 2013; 3(3): 89–99. https://doi.org/10.5319/wjo.v3.i3.89Rai V., Wood M.B., Feng H., Schabla N.M., Tu S., Zuo J. The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells. Sci. Rep. 2020; 10(1): 15167. https://doi.org/10.1038/s41598-020-72181-6Rai V., Wood M.B., Feng H., Schabla N.M., Tu S., Zuo J. The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells. Sci. Rep. 2020; 10(1): 15167. https://doi.org/10.1038/s41598-020-72181-6Lin F., Zheng Y., Pan L., Zuo Z. Attenuation of noisy environment-induced neuroinflammation and dysfunction of learning and memory by minocycline during perioperative period in mice. Brain Res. Bull. 2020; 159: 16–24. https://doi.org/10.1016/j.brainresbull.2020.03.004Lin F., Zheng Y., Pan L., Zuo Z. Attenuation of noisy environment-induced neuroinflammation and dysfunction of learning and memory by minocycline during perioperative period in mice. Brain Res. Bull. 2020; 159: 16–24. https://doi.org/10.1016/j.brainresbull.2020.03.004Cui B., Su D., Li W., She X., Zhang M., Wang R. et al. Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease. J. Neuroinflammation. 2018; 15(1): 190. https://doi.org/10.1186/s12974-018-1223-4Cui B., Su D., Li W., She X., Zhang M., Wang R. et al. Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease. J. Neuroinflammation. 2018; 15(1): 190. https://doi.org/10.1186/s12974-018-1223-4Wang Q., Shen Y., Hu H., Fan C., Zhang A, Ding R et al. Systematic Transcriptome Analysis of Noise-Induced Hearing Loss Pathogenesis Suggests Inflammatory Activities and Multiple Susceptible Molecules and Pathways. Front Genet. 2020; 11: 968. https://doi.org/10.3389/fgene.2020.00968Wang Q., Shen Y., Hu H., Fan C., Zhang A, Ding R et al. Systematic Transcriptome Analysis of Noise-Induced Hearing Loss Pathogenesis Suggests Inflammatory Activities and Multiple Susceptible Molecules and Pathways. Front Genet. 2020; 11: 968. https://doi.org/10.3389/fgene.2020.00968Dzhambov A.M., Dimitrova D.D. Lifetime exposure to self-reported occupational noise and prevalent rheumatoid arthritis in the National Health and Nutrition Examination Survey (2011-2012). Int. J. Occup. Environ. Health. 2017; 23(3): 215–221. https://doi.org/10.1080/10773525.2018.1451809Dzhambov A.M., Dimitrova D.D. Lifetime exposure to self-reported occupational noise and prevalent rheumatoid arthritis in the National Health and Nutrition Examination Survey (2011-2012). Int. J. Occup. Environ. Health. 2017; 23(3): 215–221. https://doi.org/10.1080/10773525.2018.1451809De Roos A.J., Koehoorn M., Tamburic L., Davies H.W., Brauer M. Proximity to traffic, ambient air pollution, and community noise in relation to incident rheumatoid arthritis. Environ. Health Perspect. 2014; 122: 1075–1080. https://doi.org/10.1289/ehp.1307413De Roos A.J., Koehoorn M., Tamburic L., Davies H.W., Brauer M. Proximity to traffic, ambient air pollution, and community noise in relation to incident rheumatoid arthritis. Environ. Health Perspect. 2014; 122: 1075–1080. https://doi.org/10.1289/ehp.1307413Бараева Р.А., Бабанов С.А. Иммунный профиль при вибрационной болезни от воздействия локальной и общей вибрации. Санитарный врач. 2015; 7: 11–19.Baraeva R.A., Babanov S.A. Immune profile in vibration disease from exposure to local and general vibration. Sanitarnyj vrach. 2015; 7: 11–19 (in Russian).Бабанов С., Бараева Р. Показатели клеточного иммунитета и цитокиновый профиль при вибрационной болезни. Врач. 2017; 1: 53–56.Babanov S., Baraeva R. Cellular immunity indicators and cytokine profile in vibration disease. Vrach. 2017; 1: 53–56 (in Russian).Кирьяков В.А., Павловская Н.А., Лапко И.В., Богатырева И.А., Антошина Л.И., Ошкодеров О.А. Воздействие производственной вибрации на организм человека на молекулярно-клеточном уровне. Медицина труда и промышленная экология. 2018; 9: 34–43. https://doi.org/10.31089/1026-9428-2018-9-34-43Kiryakov V.A., Pavlovskaya N.A., Lapko I.V., Bogatyreva I.A., Antoshina L.I., Oshkoderov O.A. Impact of occupational vibration on molecular and cell level of human body. Med. truda i prom. ekol. 2018; 9: 34–43. https://doi.org/10.31089/1026-9428-2018-9-34-43 (in Russian).Castro A.P., Aguas A.P., Grande N.R., Monteiro E., Castelo N.A. Increase in CD8+ and CD4+ T-lymphocytes in patients with vibroacoustic disease. Aviat Space Environ Med. 1999; 70 (3 Pt 2): A141–A144.Castro A.P., Aguas A.P., Grande N.R., Monteiro E., Castelo N.A. Increase in CD8+ and CD4+ T-lymphocytes in patients with vibroacoustic disease. Aviat Space Environ Med. 1999; 70 (3 Pt 2): A141–A144.Курчевенко С.И., Бодиенкова Г.М., Лахман О.Л. Сравнительная характеристика субпопуляционного состава лимфоцитов и белка теплового шока у пациентов с вибрационной болезнью. Российский иммунологический журнал. 2019; 13(2–2): 846–848. https://doi.org/10.31857/S102872210006677-9Kurchevenko S.I., Bodienkova G.M., Lakhman O.L. Comparative characteristics of the subpopulation composition of lymphocytes and heat shock protein in patients with vibration disease. Rossijskij immunologicheskij zhurnal. 2019; 13(2–2): 846–848. https://doi.org/10.31857/S102872210006677-9 (in Russian).Павловская Н.А., Антошина Л.И., Сааркоппель Л.М. Действие вибрации на биохимические показатели, характеризующие окислительный метаболизм, иммунитет, обмен мышечной и соединительной тканей (обзор литературы). Медицина труда и промышленная экология. 2009; 2: 32–37.Antoshina L.I., Saarkoppel L.M., Pavlovskaya N.A. Influence of vibration on biochemical values characterizing oxidative metabolism, immunity, metabolism in muscular and connective tissues (review of literature). Med. truda i prom. ekol. 2009; 2: 32–37 (in Russian).Азовскова Т.А., Лаврентьева Н.Е. Изменение иммунного гомеостаза при воздействии производственной вибрации. Медицинский Совет. 2016; 10: 174–176. https://doi.org/10.21518/2079-701X-2016-10-174-176Azovskova T.A., Lavrentieva N.E. Сhange of immune homeostasis exposed to production vibration. Medicinskij Sovet. 2016; 10: 174–176. https://doi.org/10.21518/2079-701X-2016-10-174-176 (in Russian).Курчевенко С.И., Бодиенкова Г.М. Донозологическая диагностика вибрационной болезни. Клиническая лабораторная диагностика. 2017; 8: 482–485. https://elibrary.ru/zfmcxhKurchevenko S.I., Bodienkova G.M. The pre-nosologic diagnostic of vibration disease. Klinicheskaya Laboratornaya Diagnostika. 2017; 8: 482–485. https://elibrary.ru/zfmcxh (in Russian)Азовскова Т.А., Лаврентьева Н.Е. О роли иммунной системы в патогенезе вибрационной болезни. Фарматека. 2016; 10: 14–16.Azovskova T.A., Lavrentyeva N.E. About the role of immune system in the pathogenesis of vibration disease. Farmateka. 2016; 10: 14–16 (in Russian).Симбирцев А.С. Цитокины в патогенезе и лечении заболеваний человека. СПб: Фолиант, 2018.Simbirtsev A.S. Cytokines in the pathogenesis and treatment of human diseases. SPb: Foliant; 2018 (in Russian).Серебренникова С.Н., Семинский И.Ж. Роль цитокинов в воспалительном процессе. Сибирский медицинский журнал. 2008; 81(6): 5–8.Serebrennikova S.N., Seminsky I.Zh. The role of cytokines in the inflammatory process. Sibirskij medicinskij zhurnal. 2008; 81(6): 5–8 (in Russian).Крючкова Е.Н., Сааркоппель Л.М., Яцына И.В. Особенности иммунного ответа при хроническом воздействии промышленных аэрозолей. Гигиена и санитария. 2016; 95(11): 1058–1061. https://elibrary.ru/xsnrrbKryuchkova E.N., Saarkoppel L.M., Yatsyna I.V. Features of immune response in chronic exposure to industrial aerosols. Gigiena i sanitarija. 2016; 95(11): 1058–1061. https://elibrary.ru/xsnrrb (in Russian).Бодиенкова Г.М., Курчевенко С.И. Нейроиммуноэндокринные взаимоотношения при воздействии локальной вибрации на работающих. Медицина труда и промышленная экология. 2015; 4: 39–43.Bodienkova G.M., Kurchevenko S.I. Neuroim-mune endocrine relationships under exposure to local vibration in workers. Med. truda i prom. ekol. 2015; 4: 39–43 (in Russian).Бодиенкова Г.М., Курчевенко С.И. Взаимосвязь между концентрацией цитокинов и уровнем антител к нейрональным белкам у рабочих при воздействии вибрации. Нейрохимия. 2016; 33(1): 85–89. https://doi.org/10.7868/S1027813316010039Bodienkova G.M., Kurchevenko S.I. The relationship between the cytokine concentrations and levels of antibodies to neuronal proteins in workers who were exposed to vibration. Nejrohimija. 2016; 33(1): 85–89. https://doi.org/10.7868/S1027813316010039 (in Russian).Бодиенкова Г.М., Курчевенко С.И. Оценка медиаторов воспаления при воздействии вибрации на рабочих в зависимости от выраженности патологического процесса. Гигиена и санитария. 2017; 96(5): 460–462. https://elibrary.ru/ysqdhbBodienkova G.M., Kurchevenko S.I. Assessment of inflammation mediators under exposure to the vibration in employees in dependence on pronouncement of the pathological process. Gigiena i sanitarija. 2017; 96(5): 460–462. https://elibrary.ru/ysqdhb (in Russian)Боклаженко Е.В., Бодиенкова Г.М. Дисбаланс состава лимфоцитов и цитокинового профиля как фактор риска развития вибрационной болезни. Анализ риска здоровью. 2022; 1: 140–145. https://doi.org/10.21668/health.risk/2022.1.15Boklazhenko E.V., Bodienkova G.M. Imbalance in lymphocyte composition and cytokine profile as a risk factor of vibration disease. Analiz riska zdorov’ju. 2022; 1: 140–145. https://doi.org/10.21668/health.risk/2022.1.15 (in Russian).Бодиенкова Г.М., Курчевенко С.И., Русанова Д.В. Нейроаутоиммунные процессы при вибрационной болезни. Нейрохимия. 2018; 35(3): 269–274. https://doi.org/10.1134/S1027813318030020Bodienkova G.M., Kurchevenko S.I., Rusanova D.V. Neuroautoimmune processes in vibration disease. Nejrohimija. 2018; 35(3): 269–274. https://doi.org/10.1134/S1027813318030020 (in Russian).Rosado M.M., Simko M., Mattsson, M.O., Pioli C. Immune-Modulating Perspectives for Low Frequency Electromagnetic Fields in Innate Immunity. Front. Public Health. 2018; 6: 85. https://doi.org/10.3389/fpubh.2018.00085Rosado M.M., Simko M., Mattsson, M.O., Pioli C. Immune-Modulating Perspectives for Low Frequency Electromagnetic Fields in Innate Immunity. Front. Public Health. 2018; 6: 85. https://doi.org/10.3389/fpubh.2018.00085Manna D., Ghosh R. Effect of radiofrequency radiation in cultured mammalian cells: A review. Electromagn. Biol. Med. 2016; 35: 265–301. https://doi.org/10.3109/15368378.2015.1092158Manna D., Ghosh R. Effect of radiofrequency radiation in cultured mammalian cells: A review. Electromagn. Biol. Med. 2016; 35: 265–301. https://doi.org/10.3109/15368378.2015.1092158Szemerszky R., Zelena D., Barna I., Bardos G. Stress-related endocrinological and psychopathological effects of short-and long-term 50 Hz electromagnetic field exposure in rats. Brain research bulletin. 2010; 81(1): 92–99. https://doi.org/10.1016/j.brainresbull.2009.10.015Szemerszky R., Zelena D., Barna I., Bardos G. Stress-related endocrinological and psychopathological effects of short-and long-term 50 Hz electromagnetic field exposure in rats. Brain research bulletin. 2010; 81(1): 92–99. https://doi.org/10.1016/j.brainresbull.2009.10.015Klimek A., Rogalska J. Extremely Low-Frequency Magnetic Field as a Stress Factor — Really Detrimental? — Insight into Literature from the Last Decade. Brain Sci. 2021; 11: 174. https://doi.org/10.3390/brainsci11020174Klimek A., Rogalska J. Extremely Low-Frequency Magnetic Field as a Stress Factor — Really Detrimental? — Insight into Literature from the Last Decade. Brain Sci. 2021; 11: 174. https://doi.org/10.3390/brainsci11020174Piszczek P., Wójcik-Piotrowicz K., Gil K., Kaszuba-Zwoińska J. Immunity and electromagnetic fields. Environ Res. 2021; 200: 111505. https://doi.org/10.1016/j.envres.2021.111505Piszczek P., Wójcik-Piotrowicz K., Gil K., Kaszuba-Zwoińska J. Immunity and electromagnetic fields. Environ Res. 2021; 200: 111505. https://doi.org/10.1016/j.envres.2021.111505Pall M.L. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. J Cell Mol Med. 2013; 17(8): 958–965. https://doi.org/10.1111/jcmm.12088Pall M.L. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. J Cell Mol Med. 2013; 17(8): 958–965. https://doi.org/10.1111/jcmm.12088Yao C., Zhao L., Peng R. The biological effects of electromagnetic exposure on immune cells and potential mechanisms. Electromagn Biol Med. 2022; 41(1): 108–117. https://doi.org/10.1080/15368378.2021.2001651Yao C., Zhao L., Peng R. The biological effects of electromagnetic exposure on immune cells and potential mechanisms. Electromagn Biol Med. 2022; 41(1): 108–117. https://doi.org/10.1080/15368378.2021.2001651Ichinose T.Y., Burch J.B., Noonan C.W., Yost M.G., Keefe T.J., Bachand A. et al. Immune markers and ornithine decarboxylase activity among electric utility workers. J. Occup. Environ. Med. 2004; 46(2): 104–112. https://doi.org/10.1097/01.jom.0000111963.64211.3bIchinose T.Y., Burch J.B., Noonan C.W., Yost M.G., Keefe T.J., Bachand A. et al. Immune markers and ornithine decarboxylase activity among electric utility workers. J. Occup. Environ. Med. 2004; 46(2): 104–112. https://doi.org/10.1097/01.jom.0000111963.64211.3bBoscolo P., Bergamaschi A., Di Sciascio M.B., Benvenuti F., Reale M., Di Stefano F. et al. Effects of low frequency electromagnetic fields on expression of lymphocyte subsets and production of cytokines of men and women employed in a museum. Sci. Total Environ. 2001; 270(1–3): 13–20. https://doi.org/10.1016/s0048-9697(00)00796-8Boscolo P., Bergamaschi A., Di Sciascio M.B., Benvenuti F., Reale M., Di Stefano F. et al. Effects of low frequency electromagnetic fields on expression of lymphocyte subsets and production of cytokines of men and women employed in a museum. Sci. Total Environ. 2001; 270(1–3): 13–20. https://doi.org/10.1016/s0048-9697(00)00796-8Boscol P., Di Sciascio M.B., D’Ostilio S., Del Signore A., Reale M., Conti P. et al. Effects of electromagnetic fields produced by radiotelevision broadcasting stations on the immune system of women. Sci Total Environ. 2001; 273(1–3): 1–10. https://doi.org/10.1016/s0048-9697(01)00815-4Boscol P., Di Sciascio M.B., D’Ostilio S., Del Signore A., Reale M., Conti P. et al. Effects of electromagnetic fields produced by radiotelevision broadcasting stations on the immune system of women. Sci Total Environ. 2001; 273(1–3): 1–10. https://doi.org/10.1016/s0048-9697(01)00815-4Gobba F., Bargellini A., Bravo G., Scaringi M., Cauteruccio L., Borella P. Natural killer cell activity decreases in workers occupationally exposed to extremely low frequency magnetic fields exceeding 1 microT. Int J Immunopathol Pharmacol. 2009; 22(4): 1059–1066. https://doi.org/10.1177/039463200902200422Gobba F., Bargellini A., Bravo G., Scaringi M., Cauteruccio L., Borella P. Natural killer cell activity decreases in workers occupationally exposed to extremely low frequency magnetic fields exceeding 1 microT. Int J Immunopathol Pharmacol. 2009; 22(4): 1059–1066. https://doi.org/10.1177/039463200902200422Bonhomme-Faivre L., Marion S., Bezie Y., Auclair H., Fredj G., Hommeau C. Study of human neurovegetative and hematologic effects of environmental low-frequency (50-Hz) electromagnetic fields produced by transformers. Arch. Environ. Health. 1998; 53(2): 87–92. https://doi.org/10.1080/00039896.1998.10545968Bonhomme-Faivre L., Marion S., Bezie Y., Auclair H., Fredj G., Hommeau C. Study of human neurovegetative and hematologic effects of environmental low-frequency (50-Hz) electromagnetic fields produced by transformers. Arch. Environ. Health. 1998; 53(2): 87–92. https://doi.org/10.1080/00039896.1998.10545968Tuschl H., Neubauer G., Schmid G., Weber E., Winker N. Occupational exposure to static, ELF, VF and VLF magnetic fields and immune parameters. Int. J. Occup. Med. Environ. Health. 2000; 13(1): 39–50.Tuschl H., Neubauer G., Schmid G., Weber E., Winker N. Occupational exposure to static, ELF, VF and VLF magnetic fields and immune parameters. Int. J. Occup. Med. Environ. Health. 2000; 13(1): 39–50.

The authors declare that there are no conflicts of interest present.