Introduction. Since March 2020, the introduction of a self-isolation regime and significant restrictions on personal contacts at work and school in connection with the COVID-19 pandemic has led to an expansion of the introduction of information technologies and a sharp restriction of direct interpersonal communication. The introduction of these restrictions has had a stressful effect on the body of both workers and students of various age groups, including young people. For a successful analysis of the impact of COVID-19 restrictions on the psychophysiological state of these categories of young workers and students, it seems appropriate to assess the state of maladaptation, self-assessment of nervous and somatic well-being.

The study aims to assess the impact on the adaptive psychophysiological parameters of young trade workers and students of the changed working and study conditions against the background of the COVID–19 epidemic situation (self-isolation).

Materials and methods. The object of the study was two groups of people who have a wide range of communication with colleagues and people around them, but differ in the content of their activities: students and trade workers. Scientists have conducted the study in two stages: before the pandemic (2013) and during the pandemic (December 2020) due to drastic changes in the algorithm of existence and work/study. We have examined 119 students aged 20–24 years (RGSU). There were 61 people at the first stage of the study (2013), there were 58 people at the second stage (2020, December). The second group (trade workers): 66 people aged 20–29 years. At the first stage of the study (2013), 34 people were included, at the second stage — 32 people. Experts have carried out the assessment of the psychophysiological parameters of the examined according to the questionnaire of neuropsychiatric maladjustment (ONPD). The condition for inclusion in the groups in 2020–2021 is the absence of a history of transferred COVID-19.

Results. During the tense epidemic situation (2019-2021), against the background of the spread of COVID-19 and forced self-isolation of all population groups, the lifestyle has radically changed. Face-to-face communication has been minimized, but communication using information technology in all spheres of life (daily life, study, work) has increased dramatically. The researchers found that among the surveyed population groups (students and sales workers), the spread of signs of mental discomfort increased.

Limitations. The study was limited to a sample of age groups: 20–24 years for students, 20–29 years for trade workers (in both periods).

Conclusion. The calculation of the odds ratio (OR) allowed us to establish with a high degree of confidence that signs of mental discomfort, including asthenic and depressive signals, were significantly more often recorded during the period of self-isolation in both study groups: for students who are on distance learning (December 2020 compared to 2013): the coefficient of OR=5.4, (χ2=14.7; p<0.001); for sales workers: coefficient OR=15.0; (χ2=9.5; p<0.001).

Ethics. Questions whose content does not meet ethical standards were not included in the study, as a result of which the conclusion of the biomedical ethics committee or other documents was not required.

Contribution:Yakovleva T.P. — research concept and design, material collection and data processing, statistical processing, text writing;Gaponenko A.V. — collecting material, writing text;Soshenko M.V. — collecting material, editing;Rubtsov M.Yu. — research concept, editing.

Gratitude. The authors express their gratitude to Olga Igorevna Yushkova, Dr. of Sci. (Med.), for a useful discussion.

Funding. The study had no funding.

Conflict of interests. The authors declare no conflict of interests.

Received: 26.02.2022 / Accepted: 09.03.2023 / Published: 10.04.2023