zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2022-62-5-322-330zurniimtpe-2973Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWРоль молекулярно-биологических особенностей организма в развитии профессиональной нейросенсорной тугоухостиThe role of molecular-biological characteristics of the organism in the development of professional sensorineural hearing losshttps://orcid.org/0000-0001-9822-7075ФунтиковаИнна СергеевнаFuntikovaInna S.

Врач-оториноларинголог ГБУЗ НСО «Государственная Новосибирская областная клиническая больница».

e-mail: innafuntikova54@mail.ru

An otorhinolaryngologist of the State Medical Institution of the State Novosibirsk Regional Clinical Hospital.

e-mail: innafuntikova54@mail.ru

innafuntikova54@mail.ruСмирноваЕ. Л.SmirnovaElena L.noemail@neicon.ruhttps://orcid.org/0000-0002-1422-4211ПотеряеваЕ. Л.PoteryaevaElena L.noemail@neicon.ruМаксимовВ. Н.MaksimovVladimir N.noemail@neicon.ruГБУЗ НСО «Государственная Новосибирская областная клиническая больница»РоссияNovosibirsk State regional clinical hospitalRussian FederationФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; Научно-исследовательский институт терапии и профилактической медицины - филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»РоссияNovosibirsk State Medical University; Research Institute of Therapy and Preventive Medicine - Branch of Federal Research Center Institute of Cytology and GeneticsRussian FederationФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; ФБУН «Новосибирский научно-исследовательский институт гигиены» РоспотребнадзораРоссияNovosibirsk State Medical University; Novosibirsk Research Institute of Hygiene, RospotrebnadzorRussian FederationНаучно-исследовательский институт терапии и профилактической медицины - филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»РоссияResearch Institute of Therapy and Preventive Medicine - Branch of Federal Research Center Institute of Cytology and GeneticsRussian Federation202221072022625322330Copyright © Фунтикова И.С., Смирнова Е.Л., Потеряева Е.Л., Максимов В.Н., 20222022Фунтикова И.С., Смирнова Е.Л., Потеряева Е.Л., Максимов В.Н.Funtikova I.S., Smirnova E.L., Poteryaeva E.L., Maksimov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/2973

Проведён анализ данных, имеющихся в отечественных и зарубежных источниках литературы о современном представлении и роли молекулярно-биологических особенностей организма в развитии профессиональной нейросенсорной тугоухости. Генетически обусловленная нейросенсорная тугоухость встречается в развитых странах в два раза чаще, чем в слаборазвитых. Нарушение слуха затрагивает до 30% мирового сообщества, а 70 миллионов человек являются глухими. Целый спектр современных исследований посвящен изучению вклада генетических факторов в формирование фенотипических особенностей развития и течения ряда профессиональных заболеваний. Анализ ассоциаций генетических маркеров с профессиональными заболеваниями позволяет выявить среди работающих группы лиц повышенного риска развития отдельных заболеваний и разрабатывать меры своевременной профилактики. Результаты проведённого анализа литературы позволили систематизировать данные изучения влияния молекулярно-биологических особенностей организма на формирование нейросенсорной тугоухости. Представлены данные об изученных генах-кандидатах предрасположенности к индуцируемой шумом нейросенсорной тугоухости. Углублённый анализ результатов последних исследований показал, что основными мишенями при анализе генетических факторов предрасположенности к профессиональной нейросенсорной тугоухости (ПНСТ) являются гены, кодирующие белки систем активации и регуляции фактора теплового шока, обезвреживания активных форм кислорода и передачи сигналов иммунной системы.

Этика

Этика. Исследование проведено с соблюдением этических принципов проведения медицинских исследований с участием человека в качестве субъекта; личная ответственность авторов за полученные в исследовании выводы и результаты; конфиденциальность, нераспространение информации; научная обоснованность применяемых исследовательских методов и методик; объективность в рамках интерпретации результатов, выводов; профессиональная компетентность (самоуважение и самоограничение).

Участие авторов

Участие авторов:Фунтикова И.С. — концепция и дизайн исследования, сбор материала для исследования, написание текста рукописи;Смирнова Е.Л. — концепция и дизайн исследования, обзор публикаций по теме статьи, редактирование текста рукописи;Потеряева Е.Л. — концепция и дизайн исследования, редактирование текста рукописи;Максимов В.Н. — концепция и дизайн исследования, редактирование текста рукописи

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Дата поступления

Дата поступления: 28.01.2022 / Дата принятия к печати: 18.05.2022 / Дата публикации: 25.06.2022

The researchers have analyzed the data available in domestic and foreign literature sources on the modern representation and the role of molecular biological features of the body in the development of professional sensorineural hearing loss is carried out. Genetically determined sensorineural hearing loss occurs twice as often in developed countries as in underdeveloped ones. Hearing impairment affects up to 30% of the global community, and 70 million people are deaf. Modern scientists devote their research to the study of the contribution of genetic factors in the formation of phenotypic features of the development and course of a number of occupational diseases. The analysis of genetic markers associations with occupational diseases makes it possible to identify groups of people with an increased risk of developing certain diseases among workers and to develop timely preventive measures. The results of the literature analysis made it possible to systematize the data on the study of the influence of molecular biological characteristics of the body on the formation of sensorineural hearing loss. The researchers presented the data on the studied candidate genes of predisposition to noise-induced sensorineural hearing loss. An in-depth analysis of the results of recent studies shows that the main targets in the analysis of genetic factors of predisposition to professional sensorineural hearing loss are genes encoding proteins of the systems of activation and regulation of the heat shock factor, neutralization of reactive oxygen species and transmission of signals of the immune system.

Ethics

Ethics. The authors have conducted the study in compliance with the ethical principles of conducting medical research with the participation of a person as a subject; personal responsibility of the authors for the conclusions and results obtained in the study; confidentiality, non-proliferation of information; scientific validity of the research methods and techniques used; objectivity in the interpretation of results, conclusions; professional competence (self-respect and self-restraint).

Contribution

Contribution:Funtikova I.S. — concept and design of the study, collecting material for research, writing the text of the manuscript;Smirnova E.L. — concept and design of the study, review of publications on the topic of the article, editing the text of the manuscript;Poteryaeva E.L. — concept and design of the study, editing the text of the manuscript;Maksimov V.N. — concept and design of the study, editing the text of the manuscript.

Funding

Funding. The study had no funding.

Conflict of interests

Conflict of interests. The authors declare no conflict of interests.

Received

Received: 28.01.2022 / Accepted: 18.05.2022 / Published: 25.06.2022

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The authors declare that there are no conflicts of interest present.