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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zurniimtpe</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина труда и промышленная экология</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Occupational Health and Industrial Ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1026-9428</issn><issn pub-type="epub">2618-8945</issn><publisher><publisher-name>FSBSI “Izmerov Research Institute of Occupational Health”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31089/1026-9428-2019-59-11-926-930</article-id><article-id custom-type="elpub" pub-id-type="custom">zurniimtpe-1437</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Особенности факторов риска развития производственно обусловленной патологии у работников металлургического производства</article-title><trans-title-group xml:lang="en"><trans-title>Features of risk factors of development of the production caused pathology at workers of metallurgical production</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Власова</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Vlasova</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Для корреспонденции: Власова Елена Михайловна, зав. центром профпатологии, кандидат медицинских наук наук. </p><p>ул. Монастырская, 82, Пермь, 614045</p></bio><bio xml:lang="en"><p>Elena M. Vlasova</p><p>82, Monastyrskaya str., Perm, Russia, 614045</p></bio><email xlink:type="simple">vlasovaem@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полевая</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Polevaya</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порошина</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Poroshina</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Mariya M. Poroshina</p><p>82, Monastyrskaya str., Perm, Russia, 614045</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тиунова</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tiunova</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Мariya I. Tiunova</p><p>82, Monastyrskaya str., Perm, Russia, 614045</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеев</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseev</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Vadim B. Alekseev</p><p>82, Monastyrskaya str., Perm, Russia, 614045</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Scientific Center for Medical and Preventive Health Risk Management Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>11</issue><fpage>926</fpage><lpage>930</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Власова Е.М., Полевая Е.А., Порошина М.М., Тиунова М.И., Алексеев В.Б., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Власова Е.М., Полевая Е.А., Порошина М.М., Тиунова М.И., Алексеев В.Б.</copyright-holder><copyright-holder xml:lang="en">Vlasova E.M., Polevaya E.A., Poroshina M.M., Tiunova M.I., Alekseev V.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.journal-irioh.ru/jour/article/view/1437">https://www.journal-irioh.ru/jour/article/view/1437</self-uri><abstract><sec><title>Введение</title><p>Введение. Актуальность исследования сердечно-сосудистых заболеваний (ССЗ) как производственно обусловленной патологии у работающих на промышленных предприятиях обусловлена наличием в технологическом процессе производственных факторов (шум, общая вибрация, микроклимат, тяжесть труда, химические факторы), потенциально способных провоцировать развитие ССЗ.</p><p>Цель исследования — оценка респираторных и метаболических нарушений, являющихся факторами риска развития ССЗ, у работающих в условиях воздействия пыли, хлора и хлороводорода.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Обследованы 139 пациентов, работающих в условиях воздействия пыли, хлора и хлороводорода. Среди обследованных 74 женщины и 65 мужчин. Группа сравнения (45 человек) состояла из 20 женщин и 25 мужчин, которые в процессе трудовой деятельности не подвергались воздействию вредных факторов производства. </p></sec><sec><title>Результаты</title><p>Результаты. В группе работников, подвергающихся профессиональному воздействию пыли, паров хлора и гидрохлорида, выявлено, что доля работников с артериальной гипертензией составила 33,3%, в группе сравнения — 17,6%, р&lt;0,05 (RR 1,99; 95% CI 1,01–3,93; EF=47%; степень профессиональной обусловленности средняя). Объем форсированного выдоха за 1 секунду (ОФВ1) в группе наблюдения составил 3,18±0,14 л, а в группе сравнения — 4,1±0,20 л (р&lt;0,001). Уровень общего холестерина в группе наблюдения составил 5,72±0,13 ммоль/л, а в группе сравнения — 5,16±0,23 ммоль/л (р&lt;0,05). В группе наблюдения было выявлено снижение ЛПВП (1,35±0,04 ммоль/л против 1,64±0,10 ммоль/л в группе сравнения, р&lt;0,05) и повышение триглицеридов (2,3±0,17 ммоль/л против 1,51±0,16 ммоль/л в группе сравнения, р&lt;0,05).</p></sec><sec><title>Заключение</title><p>Заключение. В группе работников, подвергающихся профессиональному воздействию пыли, паров хлора и гидрохлорида, выявлено снижение скоростных параметров функции внешнего дыхания, развитие проатерогенных метаболических нарушений, повышение лабораторных показателей воспаления. Указанные изменения могут приводить к раннему манифестированию сердечно-сосудистой и респираторной патологии у данной категории работников.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The relevance of the study of cardiovascular diseases (CVD) as a production-related pathology in workers at industrial enterprises is due to the presence in the technological process of production factors (noise, general vibration, microclimate, severity of labor, chemical factors), potentially capable of provoking the development of CVD.</p><p>The aim of the study was to assess respiratory and metabolic disorders, which are risk factors for CVD, in workers exposed to dust, chlorine and hydrogen chloride.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. 139 patients working under the influence of dust, chlorine and hydrogen chloride were examined. Among the surveyed 74 women and 65 men. The comparison group (45 people) consisted of 20 women and 25 men who were not exposed to harmful factors of production during their working life.</p></sec><sec><title>Results</title><p>Results. In the group of workers exposed to occupational exposure to dust, chlorine and hydrochloride vapors, it was revealed that the proportion of workers with arterial hypertension was 33.3%, in the comparison group–17.6%, p&lt;0.05 (RR 1.99; 95% CI 1.01–3.93; EF=47%; the degree of professional conditioning is average). The volume of forced exhalation per 1 second (FEV1) in the observation group was 3.18±0.14 l, and in the comparison group–4.1±0.20 l (p&lt;0.001). The level of total cholesterol in the observation group was 5.72±0.13 mmol / l, and in the comparison group–5.16±0.23 mmol / l (p&lt;0.05). The observation group showed a decrease in HDL (1.35±0.04 mmol / l vs. 1.64±0.10 mmol / l in the comparison group, p&lt;0.05) and an increase in triglycerides (2.3±0.17 mmol/l versus 1.51±0.16 mmol/l in the comparison group, p&lt;0.05).</p></sec><sec><title>Conclusions</title><p>Conclusions. In the group of workers exposed to professional dust, chlorine and hydrochloride vapors, a decrease in the speed parameters of the external respiratory function, the development of proatherogenic metabolic disorders, and an increase in laboratory indicators of inflammation were revealed. These changes can lead to early manifestation of cardiovascular and respiratory pathology in this category of workers.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>металлургическое производство</kwd><kwd>производственно обусловленная патология</kwd><kwd>пыль</kwd><kwd>хлор</kwd><kwd>гидрохлорид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metallurgical production</kwd><kwd>industrial pathology</kwd><kwd>dust</kwd><kwd>chlorine</kwd><kwd>hydrochloride</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шляхто Е.В. ред. Кардиология. Национальное руководство (краткое издание). М.: ГЭОТАР-Медиа; 2019.</mixed-citation><mixed-citation xml:lang="en">Shljahto E.V. Ed. Cardiology. National leadership (short edition). 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