zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2019-2-92-96zurniimtpe-1299Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWОбобщение онкоэпидемиологических исследований связи рака легкого с радономA meta-analysis of oncoepidemiological data on possible link between radon exposure and lung cancerЯрмошенкоИ. В.YarmoshenkoI. V.

ул. Софьи Ковалевской, 20а, Екатеринбург, 620990.

20a, Soph’i Kovalevskoy Str., Ekaterinburg, 620990.

МалиновскийГ. П.MalinovskiyG. P.

ул. Софьи Ковалевской, 20а, Екатеринбург, 620990.

20a, Soph’i Kovalevskoy Str., Ekaterinburg, 620990.

ВасильевА. В.Vasil’yevA. V.

ул. Софьи Ковалевской, 20а, Екатеринбург, 620990.

20a, Soph’i Kovalevskoy Str., Ekaterinburg, 620990.

ФГБУН «Институт промышленной экологии Уральского отделения РАН».РоссияInstitute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences.Russian Federation201912032019029296Copyright © Ярмошенко И.В., Малиновский Г.П., Васильев А.В., 20192019Ярмошенко И.В., Малиновский Г.П., Васильев А.В.Yarmoshenko I.V., Malinovskiy G.P., Vasil’yev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/1299

Радон и его дочерние продукты (ДПР) — глобальный природный фактор радиационного воздействия на человека. Новые данные о факторах риска рака легкого, а также значительный объем результатов эпидемиологических и медико-статистических исследований, выполненных в последнее время в разных регионах мира, делают актуальным обобщенный анализ сведений о связи рака легкого с облучением радоном в жилищах. Проведен анализ наиболее полного набора результатов исследований эффектов облучения радоном для здоровья человека, выполненных на основе подхода с использованием агрегированных по территориальному признаку медико-статистических данных и исследований по принципу случай-контроль. Обобщены результаты регрессионного анализа зависимости смертности от рака легкого от среднего уровня накопления радона в зданиях регионов России и США и мета-анализа более 30 исследований по принципу случай-контроль, выполненных в разных регионах мира. Результаты исследования подтверждают связь рака легкого с облучением радоном в жилищах. Для оценки риска рака легкого, индуцированного радоном, может быть рекомендована величина 0,14 (с 90% доверительным интервалом 0,10–0,18), нормированная на экспозицию по дочерним продуктам радона, соответствующую объемной активности радона 100 Бк/м3. Радон обусловливает около 6% заболеваемости и смертности от рака легкого в России, что соответствует количеству более 3000 новых случаев в год.

Radon and its derivatives are a global natural factor of radiation infl uence on humans. New data on risk factors of lung cancer and signifi cant volume of epidemiologic and medical statistic data collected recently in various parts of the world prove that meta-analysis of information of link between lung cancer and radon exposure in living area is topical. Th e authors analyzed the most complete set of data on radon infl uence on human health, based on use of territory-wise aggregation of medical statistic materials and case-control research results. Summary covered also results of regression analysis of dependence of lung cancer mortality on average level of radon accumulation in buildings of Russian and US regions, and meta-analysis of over 30 case-control studies performed in various parts of the world. Th e study results support relations between lung cancer and radon irradiation in houses. To evaluate risk of lung cancer induced by radon, one can recommend value of 0.14 (with 90% confi dence interval 0.10–0.18) normalized for exposure to radon derivatives and corresponding to radon volumetric activity of 100 Bq/m3. Radon causes nearly 6% of lung cancer morbidity and mortality in Russia — that is over 3,000 new cases per year.

радонрак легкогорискradonlung cancerriskReferencesUnited Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). United Nations Report 2000 — Annex B: exposures from natural radiation sources. New York: UNSCEAR; 2000.United Nations Scientifi c Committ ee on the Eff ects of Atomic Radiation (UNSCEAR). United Nations Report 2000 — Annex B: exposures from natural radiation sources. New York: UNSCEAR; 2000.United Nations Environment Programme (UNEP). Radiation: eff ects and sources. Austria: UNEP; 2016. ISBN: 978–92– 807–3517–8.United Nations Environment Programme (UNEP). Radiation: eff ects and sources. Austria: UNEP; 2016. ISBN: 978–92– 807–3517–8.Yarmoshenko I. Vasil’yev A., Malinovskiy G., Bossew P., Žunić Z.S., Onishchenko A., Zhukovskiy M. Variance of indoor radon concentration: Major infl uencing factors. Science of the Total Environment. 2016; 541: 155–60.Yarmoshenko I. Vasil’yev A., Malinovskiy G., Bossew P., Žunić Z.S., Onishchenko A., Zhukovskiy M. Variance of indoor radon concentration: Major infl uencing factors. Science of the Total Environment. 2016; 541: 155–60.Шандала Н.К., Семенова М.П., Исаев Д.В., Киселев С.М., Серегин В.А., Титов А.В. и др. Радиоэкологическая обстановка в районе расположения приаргунского производственного горно-химического объединения. Гигиена и сан. 2014; 93(4): 14–8.Shandala N.K., Semyonova M.P., Isayev D.V., Kiselev S.M., Seregin V.A., Titov A.V. Th e radioecological status of the Priargunsky Industrial Mining and Chemical Union territory. Gigiyena i san. 2014; 93(4): 14–8. (in Russian)Žunic Z.S., I. Čeliković I., Demajo A., Ujić P., Yarmoshenko I.V., Birovljev A., et al. Radon survey in the high natural radiation region of Niška Banja, Serbia. J Environ Radioact. 2007; 92(3): 165–74.Žunic Z.S., I. Čeliković I., Demajo A., Ujić P., Yarmoshenko I.V., Birovljev A., et al. Radon survey in the high natural radiation region of Niška Banja, Serbia. J Environ Radioact. 2007; 92(3): 165–74.International Commission on Radiological Protection (ICRP). Occupational radiological protection in interventional procedures. ICRP Publication 139. Ann. ICRP. 47 (2); 2018.International Commission on Radiological Protection (ICRP). Occupational radiological protection in interventional procedures. ICRP Publication 139. Ann. ICRP. 47 (2); 2018.International Commission on Radiological Protection (ICRP). Protection Against Radon–222 at Home and at Work. ICRP Publication 65. Ann. ICRP. 23 (2); 1993.International Commission on Radiological Protection (ICRP). Protection Against Radon–222 at Home and at Work. ICRP Publication 65. Ann. ICRP. 23 (2); 1993.Ярмошенко И.В. Радон как фактор облучения населения России. Биосферная совместимость: человек, регион, технологии. 2017; 2 (18): 108–16.Yarmoshenko I.V. Radon as a radiation exposure factor for the population of Russia. Biosfernaya sovmestimost’: chelovek, region, tekhnologii. 2017; 2 (18): 108–16 (in Russian)Lubin J.H., Boice J.D., Edling C., Hornung R.W., Howe G., Kunz E., et al. Radon and lung cancer risk: A joint analysis of 11 underground miner studies. Bethesda, MD: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health (NIH Publication no. 94–3644); 1994.Lubin J.H., Boice J.D., Edling C., Hornung R.W., Howe G., Kunz E., et al. Radon and lung cancer risk: A joint analysis of 11 underground miner studies. Bethesda, MD: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health (NIH Publication no. 94–3644); 1994.Committ ee on Health Risks of Exposure to Radon (BEIR VI). Health eff ects of exposure to radon. Washington, D.C.: National Academy Press; 1999.Committ ee on Health Risks of Exposure to Radon (BEIR VI). Health eff ects of exposure to radon. Washington, D.C.: National Academy Press; 1999.Lubin J.H., Boice JD. Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. J Natl Cancer Inst. 1997; 89: 49–57.Lubin J.H., Boice JD. Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. J Natl Cancer Inst. 1997;89: 49–57.Ярмошенко И.В., Кирдин И.А., Жуковский М.В., Астраханцева С.Ю. Мета-анализ эпидемиологических исследований риска рака легкого при облучении радоном в жилищах. Медицинская радиология и радиационная безопасность. 2003; 48(5): 33–43.Yarmoshenko I.V., Kirdin I.A., Zhukovskiy M.V., Astrakhantseva S.Yu. Meta-analysis of epidemiological case-control studies of lung cancer risk under the indoor radon exposure. Meditsinskaya radiologiya i radiatsionnaya bezopasnost’. 2003; 48(5): 33–43 (in Russian).Darby S., Hill D., Auvinen A., Barros-Dios J.M., Baysson H., Bochicchio F. et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European casecontrol studies. Br. Med. J. 2004; 330: 223–6.Darby S., Hill D., Auvinen A., Barros-Dios J.M., Baysson H., Bochicchio F. et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European casecontrol studies. Br. Med. J. 2004; 330: 223–6.Krewski D., Lubin J.H., Zielinski J.M., Alavanja M., Catalan V.S., Field R.W. et al. Residential radon and risk of lung cancer. A combined analysis of 7 North American case-control studies. Epidemiology. 2005; 16 (2): 137–45.Krewski D., Lubin J.H., Zielinski J.M., Alavanja M., Catalan V.S., Field R.W. et al. Residential radon and risk of lung cancer. A combined analysis of 7 North American case-control studies. Epidemiology. 2005; 16 (2): 137–45.Malinovskiy G., Yarmoshenko I., Zhukovskiy M. Radon, smoking and HPV as lung cancer risk factors in ecological studies. Int. J. Radiat. Biol. 2018; 94: 62–9.Malinovskiy G., Yarmoshenko I., Zhukovskiy M. Radon, smoking and HPV as lung cancer risk factors in ecological studies. Int. J. Radiat. Biol. 2018; 94: 62–9.Малиновский Г.П., Ярмошенко И.В., Жуковский М.В. Радон, курение и вирус папилломы человека как факторы риска рака легкого в эпидемиологическом исследовании экологического типа. Радиационная Гигиена. 2017;10 (2): 106–14.Malinovskiy G.P., Yarmoshenko I.V., Zhukovskiy M.V. Radon exposure, smoking and human papillomavirus as risk factors for lung cancer in an ecological type epidemiological study. Radiatsionnaya Gigiyena. 2017; 10 (2): 106–14 (in Russian).Eff ects of Ionizing Radiation: United Nations Scientifi c Committ ee on the Eff ects of Atomic Radiation 2006 Report to the General Assembly, with Scientifi c Annexes — Volume II. Annex E (“Sources-to-eff ects assessment for radon in homes and workplaces”). UNSCEAR; 2009.Eff ects of Ionizing Radiation: United Nations Scientifi c Committ ee on the Eff ects of Atomic Radiation 2006 Report to the General Assembly, with Scientifi c Annexes—Volume II. Annex E (“Sources-to-eff ects assessment for radon in homes and workplaces”). UNSCEAR; 2009.Barros-Dios J.M., Ruano-Ravina A., Perez-Rios M. Castro-Bernardez M., Abal-Arca J., Tojo-Castro M. Residential radon exposure, histologic types, and lung cancer risk. A case-control study in Galicia, Spain. Cancer Epidemiol Biomarkers Prev. 2012; 21: 951–8.Barros-Dios J.M., Ruano-Ravina A., Perez-Rios M. CastroBernardez M., Abal-Arca J., Tojo-Castro M. Residential radon exposure, histologic types, and lung cancer risk. A case-control study in Galicia, Spain. Cancer Epidemiol Biomarkers Prev. 2012; 21: 951–8.Th ompson R.E., Nelson D.F., Popkin J.H., Popkin Z. Casecontrol study of lung cancer risk from residential radon exposure in Worcester County, Massachusett s. Health Phys. 2008; 94: 228–41.Th ompson R.E., Nelson D.F., Popkin J.H., Popkin Z. Casecontrol study of lung cancer risk from residential radon exposure in Worcester County, Massachusett s. Health Phys. 2008; 94: 228–41.Tomasek L. Lung cancer risk from occupational and environmental radon and role of smoking in two Czech nested case — control studies. Int J Environ Res Public Health. 2013; 10(3): 963– 79.Tomasek L. Lung cancer risk from occupational and environmental radon and role of smoking in two Czech nested case — control studies. Int J Environ Res Public Health. 2013; 10(3): 963–79.Torres-Duran M., Ruano-Ravina A., Parente-Lamelas I., Leiro-Fernandez V., Abal-Arca J., Montero-Martınez C. et al. Lung cancer in never-smokers: a case-control study in a radon-prone area (Galicia, Spain). Eur Respir J. 2014; 44: 994–1001.Torres-Duran M., Ruano-Ravina A., Parente-Lamelas I., Leiro-Fernandez V., Abal-Arca J., Montero-Martınez C. et al. Lung cancer in never-smokers: a case-control study in a radon-prone area (Galicia, Spain). Eur Respir J. 2014; 44: 994–1001.Wilcox H.B., Al-Zoughool M., Garner M.J., Jiang H., Klotz J.B., Krewski D. et al. Case-control study of radon and lung cancer in New Jersey. Radiat Prot Dosimetry. 2008; 128: 169–79.Wilcox H.B., Al-Zoughool M., Garner M.J., Jiang H., Klotz J.B., Krewski D. et al. Case-control study of radon and lung cancer in New Jersey. Radiat Prot Dosimetry. 2008; 128: 169–79.Yarmoshenko, I., Malinovskiy G., Vasily’ev A., Zhukovskiy, M. Reconstruction of national distribution of indoor radon concentration in Russia using results of regional indoor radon measurement programs. J. Env. Radioact. 2015; 150: 99–103.Yarmoshenko, I., Malinovskiy G., Vasily’ev A., Zhukovskiy, M. Reconstruction of national distribution of indoor radon concentration in Russia using results of regional indoor radon measurement programs. J. Env. Radioact. 2015; 150: 99–103.Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИРЦ» Минздрава России; 2017: 250.Kaprin A.D., Starinskiy V.V., Petrova G.V. Malignant neoplasms in Russia in 2015 (morbidity and mortality). M.: MNIOI im. P.A. Gercena fi lial FGBU «NMIRC» Minzdrava Rossii; 2017 (in Russian).

The authors declare that there are no conflicts of interest present.